C Bothiraja, Mukesh B Shinde, S Rajalakshmi, Atmaram P Pawar
C Bothiraja1 *, Mukesh B Shinde1, S Rajalakshmi 2 and Atmaram P Pawar1
1*Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra.
2Jayawantrao Sawant Institute of Pharmacy, Hadapsar, Pune – 411028, Maharashtra,
Volume - 2,
Issue - 3,
Year - 2009
Infections with the human immunodeficiency virus (HIV) are the most serious problems worldwide. Characteristic of an extracted medicinal plant is of great therapeutic significance. Emblica officinalis Linn is a valuable natural plant used in the South East Asian traditional medicine for different infection.. In this paper, aqueous extract of Emblica officinalis was prepared by cold maceration. The obtained dried extract was subjected to in-vitro anti HIV activity using viral p-24 assay as a criteria for the detection of viral load and antioxidant activity by using Beta Carotene-linoleate oxidation model. The aqueous extract (40 mg/100 ml) showed significant reduction in viral load as compared to control titer value and showed antioxidant activity. It is contributed by Flavonoids and polyphenols constituents. The results of the present study indicating that the aqueous extract of the Emblica officinalis can be used against Human Immunodeficiency Virus type 1. Being antioxidant, it can be used to prevent neurological diseases (damage of brain cell mitochondria ) by HIV.
Cite this article:
C Bothiraja, Mukesh B Shinde, S Rajalakshmi, Atmaram P Pawar. In Vitro Anti-HIV-Type 1 and Antioxidant activity of Emblica officinalis. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 556-558.