Author(s): Balamurugan Gunasekaran, P Muralidharan

Email(s): balamurugangunasekaran@gmail.com

DOI: Not Available

Address: Balamurugan Gunasekaran* and P Muralidharan
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Thoraipakkam, Chennai-600 097, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Abutilon indicum Linn (Sweet) (Malvaceae) leaves were extracted with water and evaluated for its antinociceptive effects by employing various models such as acetic acid-induced writhing test, tail immersion test, hotplate method and formalin-induced nociceptive test. The extract at 200 and 400 mg / kg concentration significantly (p<0.01) reduced the number of writhes produced by acetic acid (0.6 %) and significantly increased the reaction time in thermal models such as hot water tail immersion, hot plate method and formalin-induced test in a dose dependent manner (p<0.01). Morphine (7.5 mg / kg) and Indomethacin (10 mg /kg) were employed as the standard drugs for comparison. The results of the present study revealed that the aqueous extract of leaves of Abutilon indicum exhibits a potential analgesic effect, which may be mediated by both central and peripheral mechanisms.


Cite this article:
Balamurugan Gunasekaran, P Muralidharan. Antinociceptive Effect of Abutilon indicum Linn Leaf extract. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 544-547.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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