Author(s): Kalpana Vasanthan, Bala Krishnan S, Shantha Arcot, Vijayageetha R

Email(s): kalpana.vasanthan@gmail.com

DOI: Not Available

Address: Kalpana Vasanthan1, Bala Krishnan S2, Shantha Arcot1 and Vijayageetha R1
1Department of Pharmaceutical analysis, C.L.Baid Metha College of Pharmacy, Jyothinagar, Thoraipakkam .Chennai-600 097, Tamilnadu. India.
2Orchid Chemical and Pharmaceutical Ltd (R&D), Shollinganallur, Chennai, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
A simple method for the detection of Benzenesulphonic acid content in Amlodipine Besylate drug substance using ion chromatography with suppressed conductivity detection is presented. A mixture of 1.3 mM Sodium carbonate and 2.0 mM Sodium bicarbonate was used as an eluant. The method showed linear responses over the sample target concentration ranges 35-65µg/ml.The correlation coefficient was found to be 0.9985.The accuracy of the method was determined by preparing the sample concentration in the ranges 70%, 100% and 130% in triplicate and the % recovery was found to be within 98.0 to 102.0.The Method precision and the intermediate precision were demonstrated by the relative standard deviations (R.S.D) of <1% for both the analyst. The Ruggedness was determined by changing the variables such as column, instrument and different analyst on different days. The method was fully validated for the determination of Benzenesulphonic acid in Amlodipine Besylate drug substance.


Cite this article:
Kalpana Vasanthan, Bala Krishnan S, Shantha Arcot, Vijayageetha R. Determination of Benzenesulphonic Acid in Amlodipine Besylate Drug Substance by Ion Chromatography with Suppressed Conductivity Detection. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 517-520.

Cite(Electronic):
Kalpana Vasanthan, Bala Krishnan S, Shantha Arcot, Vijayageetha R. Determination of Benzenesulphonic Acid in Amlodipine Besylate Drug Substance by Ion Chromatography with Suppressed Conductivity Detection. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 517-520.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-3-63


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DOI: 10.5958/0974-360X 

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