Author(s): Pradip P Gade, Mohd. Majid Iqbal, K Sreenivasa Rao

Email(s): pradippharmaceutics@gmail.com

DOI: Not Available

Address: Pradip P Gade*, Mohd. Majid Iqbal1 and K Sreenivasa Rao1
1Department of Pharmaceutics. R.R.K. Samithi’s college of Pharmacy, Bidar, Karnataka, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Floating matrix tablets of cefixime trihydrate were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Cefixime trihydrate was chosen as a model drug because it is well absorbed from stomach and upper part of small intestine. A simple Spectrophotometric method has been employed for the estimation of cefixime. This method is based on the formation of yellow to yellowish brown complex of cefixime with palladium (II) chloride in the presence of sodium lauryl sulphate. The tablets were prepared by direct compression technique, using polymer such as hydroxy propyl methyl cellulose (HPMC K4M), sodium CMC and carbopol 934P in different combinations with other standard excipients like sodium bicarbonate and lactose. Sodium bicarbonate used as gas generating agent and lactose was used as filler. Magnesium stearate used as lubricant. Tablets were evaluated for physical characterization viz. hardness, friability, swelling index, floating capacity, thickness and weight variation. Further tablets were evaluated for in-vitro drug release up to 12 hr. The effect of polymer concentrations on buoyancy and drug release pattern was also studied. In-vitro drug release mechanism was evaluated by PCP V-3 software. Carbopol 934P had a negative effect on the floating properties also decreased the drug release. But Carbopol provided a firm structure to the swollen tablet. A lesser Floating lag time (FLT) and a prolonged floating duration could be achieved by varying the amount of effervescent and using different polymer concentrations. All the matrix tablets showed significantly greater swelling index due to the swelling agents like sodium CMC. The sodium CMC containing formulations had greater swelling index compared to other. Polymer swelling is crucial in determining the drug release rate and is also important for floatation. All the tablets exhibited controlled and prolonged drug release profiles and some floated over the dissolution medium for more than 12 hr. The type of polymer affects the drug release rate and the mechanism. The paddle speed affected the floating lag time and floating duration it had a negative effect on the floating properties. The optimized formulation followed the higuchi release model and showed non-fickian diffusion mechanism. It also showed no significant change in physical appearance, drug content, floatability or in-vitro drug release pattern after storage at 45o C at 75 % RH for three months.


Cite this article:
Pradip P Gade, Mohd. Majid Iqbal, K Sreenivasa Rao. Development and In-Vitro Evaluation of Gastro-Retentive Floating Drug Delivery System of Cefixime Trihydrate. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 507-512.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags