Author(s): P Narayana Raju, M Lakshmi Narasu, KNV Rao, K Shanta Kumari, K Prakash

Email(s): nrpadala@rediffmail.com

DOI: Not Available

Address: P Narayana Raju*1, M Lakshmi Narasu2, KNV Rao3, K Shanta Kumari3 and K Prakash4
1Aurobindo pharma limited, Research and development, Bachupally, Hyderabad, AP, India.
2Centre For Biotechnology, Institute of Science and Technology, JNTU, Kukatpally, Hyderabad, AP, India
3Nalanda College of Pharmacy, Charlapally, Nalgonda, AP, India
4Faculty of Pharmacy, 7th April University, Zawia, Libya
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Amoxicillin bi layer matrix tablets were prepared using cellulose acetate (CA) and cellulose acetate butyrate (CAB) as matrix polymers for the extended release of amoxicillin. The matrix tablets consists of one immediate release layer which release the drug immediately and one sustained release layer which release the drug for a prolonged period of time. The matrix tablets were prepared by direct compression method. The prepared matrix tablets were characterized for the physical properties, drug content, differential scanning calorimetry (DSC) and in vitro dissolution studies. The prepared matrix tablets were kept for accelerated stability study as per ICH guidelines for about 3 months. The prepared bi layer matrix tablets were showing good physical properties. The initial rapid drug release from the bi layer matrix tablets was observed. The drug release was extended up to 16 hours. Differential scanning calorimetric thermographs shows the stable nature of Amoxicillin tri-hydrate. The release kinetics study revealed that the prepared bi-layer matrix tablets were best fitted to the first order. All the formulations were best fitted to Higuchi model indicated that the drug release was diffusion controlled. The prepared matrix tablets were having high commercial application.


Cite this article:
P Narayana Raju, M Lakshmi Narasu, KNV Rao, K Shanta Kumari, K Prakash. Preparation and Characterization of Bi-Layer Matrix Tablets of Amoxicillin Tri-Hydrate. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 491-494.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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