ABSTRACT:
Oral controlled drug delivery system primarily aim to increase the bioavailability of drug, but the main obstacle for oral controlled2-4 drug delivery system is inability to restrain and locate dosage form within desired region of gastrointestinal tract from where the drug has maximum absorption.Floating Microspheres of Glipizide was prepared by solvent evaporation method1. A polymeric mixture of Ethyl cellulose and hydroxy propyle methyl cellulose (HPMC). Its in-vitro5-8 performance was evaluated by the usual pharmacopoeal and other tests such as drug polymer compatibility (FTIR scan), yield (%), Micrometric properties such as Tapped density, (%). Compressibility particle size analysis (by Optical Microscopy), drug entrapment efficiency, surface topography (SEM) and in-vitro release study. The % yield of microspheres was up to 83.0±0.41. The shape and surface morphology of microspheres were studied by optical microscopy and SEM, respectively.Drug loading efficiency was found to be good. On the basis of result increasing polymer ratio increased the particle size (maximum up to 200.89±16.61). In-vivo efficiency of the optimized batch GF-1 was performed in healthy normal Wistar rats (250-300gm) by measuring the hypoglycemic effect produced after oral administration.