ABSTRACT:
The objective of this study was to develop competitive sustained release tablets of Tramadol Hydrochloride which releases the drug in a sustained manner, by using different polymers and study on there effect on release pattern. The effect of HPMC K100M, HPC, ethyl cellulose, xanthan gum, sodium CMC, ckarbopol 934P, hydrogenated castor oil, with tramadol HCl in ratio (1:1) on release rate was studied. SR tablet of tramadol HCl (dose 100mg) were prepared by wet granulation, dry granulation, melt granulation and direct compression technique. In-vitro dissolution studies performed using USP apparatus type I in the phosphate buffer media (pH 6.8) upto 12 h. For 12 h release, the ratio of drug with alone carbopol 934P (1:0.8) was found to be best suited for modulating the delivery of highly water soluble drug tramadol HCl.
Cite this article:
Mukund G Tawar , Pawar M D, P D Chaudhari. Development and Evaluation of Tramadol Hydrochloride Sustained Release Tablet. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 470-473.
Cite(Electronic):
Mukund G Tawar , Pawar M D, P D Chaudhari. Development and Evaluation of Tramadol Hydrochloride Sustained Release Tablet. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 470-473. Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-3-52