ABSTRACT:
Paracetamol1, 2 is a non steroidal analgesic and antipyretic agent with minimal side effects. Chemically it is 4-hydroxy acetanilide. It is a potent antipyretic and equianalgesic with aspirin in therapeutic doses, commonly used in the conditions like headache, dysmenorrhoea. It is the most frequently prescribed antipyretic agent. It is white crystalline powder, freely soluble in ethanol (95%) and in acetone; sparingly soluble in water, very slightly soluble in dichloromethane and in ether. The drug suffers from poor bioavailability due to its poor aqueous solubility. Aqueous solubility plays and important role in the dissolution of drug in the gastrointestinal fluid. Various approaches for increasing the aqueous solubility of drugs have been reported in literature. The use of carriers as cosolvents is one such approach. The present study investigates the use of various carriers that can enhance the solubility of Paracetamol and improve its bioavailability.