ABSTRACT:
The super disintegrants acts as hydrophilic carrier for poorly water insoluble drug. so this present article investigates the solubilizing properties of superdisintegrants and hence enhancement of the dissolution profile of a model drug furosemide(poorly water insoluble) using solid dispersion (SD) with crosspovidone(POV), Crosscarmellose sodium (CAR) and sodium starch glycolate (SSG) by using kneading technique. The 1:1 (w/w) and 1:2 (w/w) solid dispersions were prepared by kneading method using solvent water and ethanol in 1:1 ratio. Dissolution studies using the USP paddle method were performed for solid dispersions of furosemide at 37 ± 0.5oC and 50 rpm in simulated gastric fluid (SGF) of pH 1.2. Fourier transformer infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. IR spectroscopy, XRD, and DSC showed change in the crystal structure towards amorphous one of furosemide (FRMD). Dissolution of furosemide improved significantly 1:2 solid dispersion indicated increase in dissolution 5.40 fold. From this study it was concluded that the solubility and dissolution of model drug furosemide was increased due to solid deposition of drug upon surface of hydrophilic and strongly swelling superdisintegrants which enhanced the wettability and dispersibility of poorly water soluble drug furosemide which is prerequisite step for poorly water soluble drug.