Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Superdisintegrants as Solubilizing Agent

Author(s): Sagar Bhise, Ganesh Chaulang, Piyush Patel, Bhavin patel, Ashok Bhosale, Sharwaree Hardikar

Email(s): piyush_lifeline@yahoo.com

DOI: Not Available

Address: Sagar Bhise, Ganesh Chaulang, Piyush Patel, Bhavin patel, Ashok Bhosale and Sharwaree Hardikar
Department of Pharmaceutic S. G. R. S. College of Pharmacy, Saswad, Pune. (MS), India 412301.
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009

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ABSTRACT:
The super disintegrants acts as hydrophilic carrier for poorly water insoluble drug. so this present article investigates the solubilizing properties of superdisintegrants and hence enhancement of the dissolution profile of a model drug furosemide(poorly water insoluble) using solid dispersion (SD) with crosspovidone(POV), Crosscarmellose sodium (CAR) and sodium starch glycolate (SSG) by using kneading technique. The 1:1 (w/w) and 1:2 (w/w) solid dispersions were prepared by kneading method using solvent water and ethanol in 1:1 ratio. Dissolution studies using the USP paddle method were performed for solid dispersions of furosemide at 37 ± 0.5oC and 50 rpm in simulated gastric fluid (SGF) of pH 1.2. Fourier transformer infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. IR spectroscopy, XRD, and DSC showed change in the crystal structure towards amorphous one of furosemide (FRMD). Dissolution of furosemide improved significantly 1:2 solid dispersion indicated increase in dissolution 5.40 fold. From this study it was concluded that the solubility and dissolution of model drug furosemide was increased due to solid deposition of drug upon surface of hydrophilic and strongly swelling superdisintegrants which enhanced the wettability and dispersibility of poorly water soluble drug furosemide which is prerequisite step for poorly water soluble drug.


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Cite this article:
Sagar Bhise, Ganesh Chaulang, Piyush Patel, Bhavin patel, Ashok Bhosale, Sharwaree Hardikar. Superdisintegrants as Solubilizing Agent. Research J. Pharm. and Tech. 2(2): April.-June.2009,;Page 387-391.

Cite(Electronic):
Sagar Bhise, Ganesh Chaulang, Piyush Patel, Bhavin patel, Ashok Bhosale, Sharwaree Hardikar. Superdisintegrants as Solubilizing Agent. Research J. Pharm. and Tech. 2(2): April.-June.2009,;Page 387-391.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-2-84


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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