ABSTRACT:
Present study was designed to investigate the effect of various processing parameters on the physical characteristics of the rifabutin (RFB) microspheres prepared by emulsion solvent diffusion using EC and EC/HPMC polymers. XRD and DSC studies were performed to determine its crystallinity. At the end of 8 hrs, more than 90 % of the drug was released by EC/HPMC microspheres; however from EC microspheres only 88 % of the drug was released after of 12 hrs. Particle size and spherical shape of the microspheres were confirmed by SEM photomicrographs. Microspheres were found to be stable and non-hygroscopic at accelerated conditions of temperature and humidity.
Cite this article:
Nighute AB, Bhise SB. Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 371-374.
Cite(Electronic):
Nighute AB, Bhise SB. Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 371-374. Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-2-80