Author(s): Nighute AB, Bhise SB

Email(s): satishbhise@gmail.com , ashok_nighute@rediffmail.com

DOI: Not Available

Address: Nighute AB and Bhise SB*
Dept. of Biopharmaceutics, Govt. College of Pharmacy, Karad – 415 124, Dist: Satara, MS, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
Present study was designed to investigate the effect of various processing parameters on the physical characteristics of the rifabutin (RFB) microspheres prepared by emulsion solvent diffusion using EC and EC/HPMC polymers. XRD and DSC studies were performed to determine its crystallinity. At the end of 8 hrs, more than 90 % of the drug was released by EC/HPMC microspheres; however from EC microspheres only 88 % of the drug was released after of 12 hrs. Particle size and spherical shape of the microspheres were confirmed by SEM photomicrographs. Microspheres were found to be stable and non-hygroscopic at accelerated conditions of temperature and humidity.


Cite this article:
Nighute AB, Bhise SB. Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 371-374.


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DOI: 10.5958/0974-360X 

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