Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Microwave-Assisted Synthesis and Evaluation of Anticancer Activity Of Substituted Acridone Analogues

Author(s): Velingkar VS, Dandekar VD

Email(s): vsvelingkar@gmail.com

DOI: Not Available

Address: Velingkar VS* and Dandekar VD
Department of Pharmaceutical Chemistry, K.M.Kundnani College of Pharmacy- Cuffe Parade, Mumbai-4000005
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009

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ABSTRACT:
Microwave-assisted organic reaction enhancement has become a very useful tool in organic synthesis and has been explored extensively since the last decade. Microwave irradiation often leads to a remarkable decrease in reaction time, increased yields and easier workup matching with green chemistry protocols. In the present work, a fast and highly efficient method for the synthesis of substituted Acridone analogues has been performed by microwave irradiation. Microwave assisted reactions have resulted in very short reaction time with considerable increase in the yields compared to those prepared under conventional conditions. The title compounds were characterized by I.R. 1HNMR, Mass spectroscopy and Elemental analysis. The synthesized compounds were screened for the in vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cells by tryphan blue exclusion method and further selected for screening in vivo anticancer activity by determining different parameters like body weight analysis, mean survival time (MST) and percentage increase in life span (%ILS).


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Cite this article:
Velingkar VS, Dandekar VD. Microwave-Assisted Synthesis and Evaluation of Anticancer Activity Of Substituted Acridone Analogues. Research J. Pharm. and Tech.2 (2): April.-June.2009; Page 366-370.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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