Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Microwave-Assisted Synthesis and Evaluation of Anticancer Activity Of Substituted Acridone Analogues

Author(s): Velingkar VS, Dandekar VD

Email(s): vsvelingkar@gmail.com

DOI: Not Available

Address: Velingkar VS* and Dandekar VD
Department of Pharmaceutical Chemistry, K.M.Kundnani College of Pharmacy- Cuffe Parade, Mumbai-4000005
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009

 View HTML        View PDF

ABSTRACT:
Microwave-assisted organic reaction enhancement has become a very useful tool in organic synthesis and has been explored extensively since the last decade. Microwave irradiation often leads to a remarkable decrease in reaction time, increased yields and easier workup matching with green chemistry protocols. In the present work, a fast and highly efficient method for the synthesis of substituted Acridone analogues has been performed by microwave irradiation. Microwave assisted reactions have resulted in very short reaction time with considerable increase in the yields compared to those prepared under conventional conditions. The title compounds were characterized by I.R. 1HNMR, Mass spectroscopy and Elemental analysis. The synthesized compounds were screened for the in vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cells by tryphan blue exclusion method and further selected for screening in vivo anticancer activity by determining different parameters like body weight analysis, mean survival time (MST) and percentage increase in life span (%ILS).


Keywords:

Cite this article:
Velingkar VS, Dandekar VD. Microwave-Assisted Synthesis and Evaluation of Anticancer Activity Of Substituted Acridone Analogues. Research J. Pharm. and Tech.2 (2): April.-June.2009; Page 366-370.


Recomonded Articles:

In vitro anticancer activity of Ethanolic and Aqueous Extracts of Peristrophe bivalvis Merrill.

Author(s): Sangeeta S. Tanavade, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule

DOI: Not Available         Access: Open Access Read More

Microwave Assisted Synthesis of Fluoro-Pyrazole Derivatives for Antiinflammatory Activity.

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Green Synthesis of Silver Nanoparticles from Carrot

Author(s): Perumal Andal, S. Tamilselvy, P. Indra Priyatharesini

DOI: 10.5958/0974-360X.2018.00509.7         Access: Open Access Read More

Effect of different Drying Technique on the Bioactive Components of Terminalia arjuna Bark

Author(s): Simmy Gupta, Jyoti Prabha Bishnoi, Rajat Singh

DOI: 10.5958/0974-360X.2019.00397.4         Access: Open Access Read More

A Review on Chitinase Synthesis from varied sources and its Applications towards Environment

Author(s): Nisha Elizabeth Sunny, S. Rajesh Kumar, S. Venkat Kumar

DOI: 10.5958/0974-360X.2018.00770.9         Access: Open Access Read More

Phytochemical screening of Terminalia arjuna and Glycyrrhiza glabra showing the effect of different drying techniques

Author(s): Simmy Gupta, Jyoti Prabha Bishnoi

DOI: 10.5958/0974-360X.2019.00259.2         Access: Open Access Read More

Effect of Natrium Alginate Concentration on Physical Characteristics, Viability and Anticancer activity of Microparticles from a Combination of Probiotics and Tomato Pasta

Author(s): Dina Warda Rosadiani, Tutiek Purwanti, Djoko Agus Purwanto

DOI: 10.5958/0974-360X.2018.00476.6         Access: Open Access Read More

The Inhibition of Ethanol Extract of Phaleria macrocarpa Stem Bark on COX-2 Expression of HCT116 Colorectal Cancer Cell Line

Author(s): Ratu Shafira Hanifah, Nadia Aida Novitarani, Fadhilah Harmen, Aryo Tedjo, Norma Nur Azizah, Rista Putrianingsih, Wilzar Fachri, Kusmardi Kusmardi

DOI: 10.5958/0974-360X.2019.00489.X         Access: Open Access Read More

A Brief Review: Biological Implications of Naphthoquinone Derivatives

Author(s): Bigyan R. Jali, R. Behura, Soumya. R. Barik, S. Parveen, Spandan. P. Mohanty, R. Das

DOI: 10.5958/0974-360X.2018.00679.0         Access: Open Access Read More

Evaluation of Anticancer activity of Ethanol extract of Bauhinia tomentosa Linn. on A549, Human Lung Carcinoma Cell lines

Author(s): Balabhaskar R, Vijayalakshmi K

DOI: 10.5958/0974-360X.2019.00460.8         Access: Open Access Read More

Amalgamation and Characterization of Hydroxyapatite Powders from Eggshell for Functional Biomedical Application

Author(s): C. Girija, M. N. Sivakumar

DOI: 10.5958/0974-360X.2018.00777.1         Access: Open Access Read More

Antiyeast, Antioxidant and Anticancer Activity of Tribulus terrestris Linn and Bougainvillea spectabilis Linn

Author(s): Mukesh Kumar D. J., Sonia K., Madhan R., Selvakumar K., Kalaichelvan P.T.

DOI: Not Available         Access: Open Access Read More

Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil

Author(s): Anilkumar J. Shinde, Shamal V. Banage, Rakesh P. Dhavale, Harinath N. More

DOI: 10.5958/0974-360X.2020.00475.8         Access: Closed Access Read More

Recent Techniques for Extraction of Natural Products

Author(s): Manish Devgun, Arun Nanda, SH Ansari, SK Swamy

DOI: Not Available         Access: Open Access Read More

Pharmacognostic and Physicochemical Studies of Embelia ribes Burm. f. Fruit used in Ayurvedic Formulations

Author(s): A. K. Meena, Anshul Sinha, M. D. Gupta, A. K. Mangal, G. Reddy, S. C. Verma, M. M. Padhi

DOI: Not Available         Access: Open Access Read More

Phytochemical and Cytotoxicity Analysis of Seeds and Leaves of Adenanthera pavonina

Author(s): Ritika Chauhan, Hezel Lizia D’Souza, Shabnam RS, Jayanthi Abraham

DOI: 10.5958/0974-360X.2015.00036.0         Access: Open Access Read More

In Silico Study of secondary metabolites from leaf extract of Plumbago zeylanica

Author(s): D. Roselin Jenifer, B. R. Malathy, Jemmy Christy. H

DOI: 10.5958/0974-360X.2020.00016.5         Access: Closed Access Read More

Microwave assisted synthesis of novel Coumarin derivatives for its Anti-Inflammatory applications

Author(s): Shah V. V., Doijad R. C., Shah N. V.

DOI: 10.5958/0974-360X.2020.00518.1         Access: Closed Access Read More

Cytotoxicity and Antimicrobial Activity of Ipomoea batatas

Author(s): Pritha Chakraborty, Shivani Sharma, Soumita Chakraborty, Ashwini Siddapurand, Jayanthi Abraham

DOI: 10.5958/0974-360X.2018.00506.1         Access: Open Access Read More

Molecular Docking of N-benzoyl-N'-(4-fluorophenyl) thiourea Derivatives as Anticancer Drug Candidate and Their ADMET prediction

Author(s): Suko Hardjono, Tri Widiandani, Bambang T. Purwanto, Anindi L. Nasyanka

DOI: 10.5958/0974-360X.2019.00359.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



The Study of the Chemical composition of Sorption Substances
Serum level of Periostin Among Adult Asthmatic Patients
Development, Characterization and In vitro Evaluation of Donepezil solid Lipid Nanoparticles
Methylene Blue Degradation by AgCuO Bimetallic Nanomaterial, Green Synthesized using Cordia sebestena leaves
Structure-based Pharmacophore Modelling for identifying VEGFR2 Inhibitor
In silico molecular docking of Vetiver oil and formulation of Vetiver oil-Encapsulated gellan gum-based Microcapsules for Antidepressant activity
Impact of Processing on Inulin and sugars content of Jerusalem Artichoke Tuber
Studies on the Anti-inflammatory potential of selected medicinal plants in vitro
Study of Anticoagulants low molecular weight heparin and Unfractionated heparin in the management of Non-St elevation Myocardial Infarction
Synthesis, Characterization and Anti-oxidant Activity of some Novel Pyrazoline derivatives
Renoprotective effect of Corallocarpus epigaea in Nephropathy in Wistar Rats
Prevalence of antibiotic resistance and biofilm formation in Klebsiella pneumoniae carrying fimbrial genes in Egypt
Identification of Bioactive Compounds in the leaves extract of Piper longum using GCMS
Studying Some Novel Biochemical and Immunological Markers in a Sample of Iraqi Women with Polycystic Ovarian Syndrome
Comparative Studies on Total Polyphenols, Flavanoids and Antioxidant Potential ofsome Marketedbrands of packed Green Tea
Formulation and Evaluation of Oral Dispersion Tablet of Telmisartan
The Evaluation of Clinical Pharmacy services Performance at Community Health centers of sebatik island regency of Nunukan province of north Kalimantan (Indonesia-Malaysia Border)
Detection of Novel apyrimidinic Endonuclease 1 (APE1) in a sample of Iraqi cervical cancer patients using Immunohistochemistry Technique
Analgesic activity of Annona squamosa Linn fruit peels on Swis Albino mice
Heavy metal accumulation by earthworm Eisenia fetida from animal waste, soil and wheat (Triticum aestivum) for protection of human health

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 14141
Yesterday: 22555
Total: 2052958