Author(s): Srikanth Jeyabalan, Muralidharan Palayan

Email(s): srikanthcologist@rediffmail.com

DOI: Not Available

Address: Srikanth Jeyabalan and Muralidharan Palayan
Department of Pharmacology and Toxicology, C.L.Baid Metha College of Pharmacy Jyothi Nager, Thoraippakkam, Chennai-600 097.Tamilnadu, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. Literature claims that Saponins are able to reduce hyperlipidemia. Based on high saponin content in herbal plants, Sapindus emarginatus (SE) was selected and the present study focus on the anti-hyperlipidemic activity of methanol extract of pericarps of SE against Triton induced hyperlipidemia in rats. SE was administered at a dose of 100 and 200mg/kg (p.o) to Triton induced hyperlipidemic rats. Fenofibrate was used as reference standard. The statistical analyses were carried out using one way ANOVA followed by Dunnet’s multiple comparisons test.SE shows a significant decrease in the levels of serum cholesterol, phospholipid, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 100 and 200mg/kg (p.o) against Triton induced hyperlipidemic in rats. Methanol extracts decreased serum level of total cholesterol by 69.72%. On the other hand aqueous extract of SE increased the serum HDL cholesterol level by 24.11%. The reduction of LDL cholesterol level by extract was 30.31%.


Cite this article:
Srikanth Jeyabalan, Muralidharan Palayan. Antihyperlipidemic activity of Sapindus emarginatus in Triton WR-1339 induced albino rats. Research J. Pharm. and Tech.2 (2): April.-June.2009,319-323.


Recomonded Articles:

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Anis Fathima. A. G, Vara Prasanna Rao, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00385.7         Access: Open Access Read More

Author(s): Kalaivanan S, Sarumathy S, Anisha Ebens J, Naresh Kumar K, Roobena Parveen A, Nasreen Ashraf M.

DOI: 10.5958/0974-360X.2017.00005.1         Access: Open Access Read More

Author(s): Fatemeh Haidari, Esmat Mansoori, Mehrnoosh Zakerkish, Mohammadhossein Haghighizadeh

DOI: 10.5958/0974-360X.2017.00263.3         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): S.D. Ghanchi, S.C. Dhawale

DOI: Not Available         Access: Open Access Read More

Author(s): Budhwani Ashok K., Shrivastava B., Singhai A.K., Gupta Prashant

DOI: Not Available         Access: Open Access Read More

Author(s): Saher Mahmood Jwad, Bushra Abbas, Haider S. Jaffat

DOI: 10.5958/0974-360X.2015.00032.3         Access: Open Access Read More

Author(s): Nandhakumar Jothivel, Sengottuvelu Singaravel, Karthikeyan Deivasigamani, Mani Vasudevan, Sureshkumar Sundaram, Narmadha Sambasivam, Sivakumar Thangavel

DOI:         Access: Open Access Read More

Author(s): Ekaterina Borovkova, Alexander Schegolev

DOI: 10.5958/0974-360X.2018.00215.9         Access: Open Access Read More

Author(s): Senan Ibrahim, Mohammad Imad Khayat, Mohamad Ayman Awama

DOI: 10.5958/0974-360X.2018.00193.2         Access: Open Access Read More

Author(s): Manoj Jaybhaye, Pradnya Jagtap, Vaishali Unadle, Sachin Shinde, Gajanan Bhagvat, Ashwin porwal, Vishakha jagtap

DOI: 10.5958/0974-360X.2018.00918.6         Access: Open Access Read More

Author(s): Dayanand Reddy G, Bernard Mefi M, Bharathy H, Narasimha Kumar GV, Chitikela P Pullaiah, Ganesan R, Sathiya Rajeswaran P

DOI: 10.5958/0974-360X.2018.00622.4         Access: Open Access Read More

Author(s): S. Sarumathy, T. S. Shanmugarajan, K. G. Suresh Rao, N. Benazeer Begum

DOI: 10.5958/0974-360X.2018.00291.3         Access: Open Access Read More

Author(s): Shanal Smitha Alva, Himanshu Joshi, Gururaja M. P, Prasanna Shama K , Ullas P D’souza

DOI: 10.5958/0974-360X.2018.00955.1         Access: Open Access Read More

Author(s): Anti-inflammatory, Anti-oxidative and Athero-protective effects of Irbesartan in rabbits with Atherogenic diet

DOI: 10.5958/0974-360X.2018.00791.6         Access: Open Access Read More

Author(s): Saminathan Kayarohanam, Vetriselvan Subramaniyan, Ashok Kumar Janakiraman, Madhan Kumar S. J

DOI: 10.5958/0974-360X.2019.00597.3         Access: Open Access Read More

Author(s): Tayseer Shamran Al-Deresawi, Akmam Ali Habeeb

DOI: 10.5958/0974-360X.2019.00741.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags