A Novel Approach in Development of Diffusion Cell for In-Vitro Diffusion Study

Mahajan N M; Manmode AS; Sakarkar DM

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

A Novel Approach in Development of Diffusion Cell for In-Vitro Diffusion Study

Author(s): Mahajan N M, Manmode AS, Sakarkar DM

Email(s): nmmahajan78@gmail.com

DOI: Not Available

Address: Mahajan N M1*, Manmode AS2 and Sakarkar DM3
1G.S.P.S.Institute of Pharmacy, Kaulkhed, Akola (M.S.) India
2Astron Research Limited, Ahemadabad, India
3S.N. Institute of Pharmacy, Pusad, Dist.: Yavatmal (M.S.) India
*Corresponding Author

Published In: Volume - 2, Issue - 2, Year - 2009

View HTML

View PDF

ABSTRACT:
In the present study, a new design for diffusion cell was developed for in-vitro transdermal permeation. The cell consists of an inlet compartment, a donor compartment and a receptor compartment by increasing depth of an inlet compartment. This cell maintains sink condition easily as compared to static Franz diffusion cell. The performance of the cells was tested with permeation experiment using Nimesulide as a model drug for permeation through membrane. Diffusion study was carried out for the period of eight hours. Newer design was given better performance as compared to Franz Diffusion Cell. The manual sampling of the Franz cell requires constant attention during experiment. Air bubbles are easily formed in the receptor compartment while withdrawing samples. Entrapment of air bubbles was avoided in newer design by increasing depth of inlet compartment. The depth of the inlet compartment was important to avoid air bubbles entrapment in the receptor compartment in the newer design. Newer designs avoid the entrapment of air bubbles in the receptor compartment and maintain sink condition. Different transdermal gels were prepared using various gel bases. The polymers selected were Na CMC, MC and HPMC. In vitro permeation study was performed using rat skin. Formulated gel containing methyl cellulose found to be more stable. Methyl cellulose containing Nimesulide was found to better in all aspects compared to other gel formulations and this was comparable to the marketed gel.

Keywords:

Cite this article:
Mahajan N M, Manmode AS, Sakarkar DM. A Novel Approach in Development of Diffusion Cell for In-Vitro Diffusion Study. Research J. Pharm. and Tech.2 (2): April.-June.2009; Page 315-318.

Cite(Electronic):
Mahajan N M, Manmode AS, Sakarkar DM. A Novel Approach in Development of Diffusion Cell for In-Vitro Diffusion Study. Research J. Pharm. and Tech.2 (2): April.-June.2009; Page 315-318. Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-2-66

Recomonded Articles:

Formulation and Evaluation of Mucoadhesive Oral Gel Containing Miconazole Nitrate for Oral Candidiasis

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9 Access: Open Access Read More

Formulation and Evaluation of Diclofenac gel

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Antibacterial Herbal gels of Murraya koenigii Leaves Extract

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1 Access: Open Access Read More

Ocular Drug Delivery System – An Update Review

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8 Access: Open Access Read More

Formulation Development and Characterization of Etodolac Loaded Transethosomes for Transdermal Delivery

Author(s): S. B. Gondkar, Neha R. Patil, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00541.8 Access: Open Access Read More

Design and Evaluation of Nimesulide Lozenges for Pediatrics

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available Access: Open Access Read More

Topical Gels: A Review

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0 Access: Open Access Read More