Author(s): PN Sable, GM Chaulang, AV Bhosale, PD Chaudhari

Email(s): pravin_pharmacist@rediffmail.com

DOI: Not Available

Address: 1PN Sable*, 2GM Chaulang, 2AV Bhosale, and 1PD Chaudhari
1Modern College of Pharmacy Nigdi, (Pune) Maharashtra INDIA- 4110044
2,S. G. R. S. College of Pharmacy Saswad, (Pune) Maharashtra INDIA- 4110044
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
Ultraviolet absorption spectrophotometric method for the estimation of poorly water soluble drug like Olanzepine in pharmaceutical formulations has been developed. Aqueous solubility of this selected model drug was to a great extent (6 to 98 fold) in 1 M sodium benzoate, 1 M sodium acetate, 1 M sodium bicarbonate, 1M sodium chloride, 1 M sodium gluconate, 1M thiourea, 1M trisodium citrate and 1 M urea solutions. The primary objective of the present investigation was to employ these hydrotropic solutions to extract the drug from dosage forms, precluding the use of costlier organic solvents. The selected ?max for Olanzepine was 329.5 nm. The hydrotropic solutions used did not show any absorbance above 306 nm, and therefore, no interference in the estimation was seen. The results of analysis have been validated statistically, and by recovery studies. The proposed methods are new, simple, economic, accurate, safe and precise.


Cite this article:
PN Sable, GM Chaulang, AV Bhosale, PD Chaudhari. Novel Spectrophotometric Estimation of Olanzepine Using Hydrotropic Solubilizing Agents. Research J. Pharm. and Tech.2 (2): April.-June.2009,; Page 297-300


Recomonded Articles:

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Oruganti Sai Koushik, V. Himaja, P. Srinivasa Babu, Ramadoss Karthikeyan

DOI: 10.5958/0974-360X.2015.00298.X         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags