Author(s): Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad

Email(s): nitinmohire123@rediffmail.com

DOI: Not Available

Address: Nitin Chandrakant Mohire*, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad
Government College of Pharmacy, Vidyanagar, Karad. Taluka-Karad, District- Satara, Maharashtra, India- 415124.
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
Objective: Oro-dental disease or disorders are most of the times associated with acute conditions of bleeding, infection and inflammation. Presently available conventional dosage forms lack in giving prompt relief and also requires high dose to produce desired therapeutic effect. Orodispersible tablets of metronidazole overcome the drawbacks of conventional tablets by giving rapid and site specific action at low dose (10-20 times less than conventional tablets) to produce desired effect. Methods: In present work we have prepared orodispersible tablets of metronidazole by three different techniques of taste masking and three different disintegrating agents’ viz. Sodium starch glycolate (SSG), Bamboomanna (BM), Chitosan (CHN) and combination thereof. Result: All the formulations were evaluated for their pharmaceutical and clinical efficacy and among these formulations, the combination of SSG: BM and SSG: CHN in ratio 1:1 showed good results. Conclusion: Metronidazole is a choice of drug in most of the oro-dental problems. The metallic taste and large dose size limits its use in dentistry. Pleasantly flavored and taste masked orodispersible metronidazole in tablet form helps to overcome these drawbacks and thereby increases patient compliance.


Cite this article:
Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad. Novel Approaches in Development of Metronidazole Orodispersible Tablets. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 283-286.


Recomonded Articles:

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags