Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Role of Flavanoids in Free Radical Induced Hepatic Fibrosis

Author(s): Merlin NJ, V Parthasarathy, R Manavalan

Email(s): merlinbinu76@yahoo.co.in

DOI: Not Available

Address: *Merlin NJ, V Parthasarathy and R Manavalan
Department of Pharmacy, Annamalai University, Annamalai Nagar, 608002 Tamil Nadu India
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009

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ABSTRACT:
The liver is remarkably a complex organ with array of functions that have effect on nearly every other systems of the body. Molecular oxygen is an essential component of all living organisms, but higher oxidative stress leads to generation of free radicals in the process. There is accumulating evidence that these free radicals play a considerable role in the development of hepatic fibrosis by acting in different cell types and in different signaling pathways. Consequently, flavanoids, a group of phenolic compounds found naturally in fruits, vegetables, nuts, flowers, seeds and barks which are of plant origin ,have emerged as potent antifibrotic agents. Its main role as antifibrotic activity is due to its free radical scavenging activity. This review briefly summarises current views of the mechanisms of fibrogenesis and recent findings on the antihepatofibrotic potential of flavanoids.


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Cite this article:
Merlin NJ, V Parthasarathy, R Manavalan. Role of Flavanoids in Free Radical Induced Hepatic Fibrosis. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 52-57.

Cite(Electronic):
Merlin NJ, V Parthasarathy, R Manavalan. Role of Flavanoids in Free Radical Induced Hepatic Fibrosis. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 52-57.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-1-85


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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