ABSTRACT:
The present review supports the discovery, development and design of target molecules or chemical markers from Galenical to Genomical with a focus on the source, phytochemical investigation, pharmacological screening and some human safety trials of natural origin. Natural products including plants, animals, microbes and minerals, and marine have been the basis of treatment of human diseases. Considerable research on pharmacognosy, chemistry, pharmacology and clinical therapeutics has been carried out on medicinal plants. Natural product has been used traditionally for medicinal purpose. The present study highlights a modern scientific approach and evidence with respect to a traditional uses of natural product. Target molecules or chemical markers are the lead components that are complementary with traditional theme of natural things. Chemical entities from natural origin have extensive past and present use in the treatment of many diseases and serves as pyramid of interest both in their natural forms for and as template form synthetic modification. Target molecules with several other representatives of very wide chemical diversity undergoing clinical trials; continue to demonstrate the importance of compound from natural source in modern drug discovery efforts.