Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose concentration known as hyperglycemia. Diabetes mellitus covers a wide range of heterogeneous disease and involves management of its associated acute and chronic complications, thus there is every possibility of administering other drugs along with the primary anti-diabetic agent which may be the cause for a drug-drug interaction to occur. In the present study the possible pharmacodynamic interaction was studied with ramipril and gliclazide in diabetic rats. Gliclazide was studied at a dose of 7.2 mg/kg body weight in diabetic rats. Ramipril was studied at a dose of 0.90 mg/kg bodyweight in diabeic rats, for the interaction study. The drugs were administered orally and the blood samples were collected before and after administration of drug for a period of 16 h. The serum samples were then subjected to glucose estimation by glucose peroxidase method. The percentage reduction in blood glucose levels were calculated with respect to initial levels. Gliclazide showed a significant reduction of elevated and normoglycemic blood glucose levels. The extent of blood glucose reduction was comparatively increased in the case of combination therapy of ramipil and gliclazide. The study also suggests the necessity to readjust the dose of gliclazide when co-administered with ramipril.
Cite this article:
TE Gopala Krishna Murthy, C Mayuren. Effect of Ramipril on the Pharmacodynamics of Gliclazide in Diabetic Rats. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 120-122.