Ashok Malpani, S Appala Raju, SN Hiremath
Ashok Malpani1*, S Appala Raju2 and SN Hiremath3
1K.C.T. College of Pharmacy, Gulbarga-585105,
2H.K.E.S. College of Pharmacy, Gulbarga- 585105
3P.R.E.Society’s, College of Pharmacy, Chincholi, Nashik-422101
Volume - 2,
Issue - 1,
Year - 2009
Lovastatin is a hydrophobic molecule practically insoluble in aqueous media and exhibits an exceedingly slow intrinsic dissolution rate. In the present work inclusion complexes of lovastatin were prepared with the soluble complexing agents ?-CD and HP ?-CD. Phase solubility studies revealed the formation of 1:1 complex of AL type with a stability constant Kc Of 85.91 m-1 and 113.49 m-1 for ?-CD and HP ?-CD respectively in water. Interactions of the drug ?-CD and HP ?-CD in the solid state were studied using FTIR, DSC and X-ray powder diffraction studies. Preparation of kneading mixture of drug and HP?-CD increased both the aqueous solubility and the dissolution rate.
Cite this article:
Ashok Malpani, S Appala Raju, SN Hiremath. Improved Dissolution Characteristics of Lovastatin by Inclusion in -CD and Hp -CD. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 110-113.