Author(s): Ashok Malpani, S Appala Raju, SN Hiremath

Email(s): malpani_ashok@rediffmail.com

DOI: Not Available

Address: Ashok Malpani1*, S Appala Raju2 and SN Hiremath3
1K.C.T. College of Pharmacy, Gulbarga-585105,
2H.K.E.S. College of Pharmacy, Gulbarga- 585105
3P.R.E.Society’s, College of Pharmacy, Chincholi, Nashik-422101
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009


ABSTRACT:
Lovastatin is a hydrophobic molecule practically insoluble in aqueous media and exhibits an exceedingly slow intrinsic dissolution rate. In the present work inclusion complexes of lovastatin were prepared with the soluble complexing agents ?-CD and HP ?-CD. Phase solubility studies revealed the formation of 1:1 complex of AL type with a stability constant Kc Of 85.91 m-1 and 113.49 m-1 for ?-CD and HP ?-CD respectively in water. Interactions of the drug ?-CD and HP ?-CD in the solid state were studied using FTIR, DSC and X-ray powder diffraction studies. Preparation of kneading mixture of drug and HP?-CD increased both the aqueous solubility and the dissolution rate.


Cite this article:
Ashok Malpani, S Appala Raju, SN Hiremath. Improved Dissolution Characteristics of Lovastatin by Inclusion in -CD and Hp -CD. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 110-113.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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