Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Development and Characterization of Cellulose and Eudragit Gastroretentive Floating Microspheres of Acyclovir

Author(s): Rajeev Garg, GD Gupta

Email(s): indianpharmacist@sify.com

DOI: Not Available

Address: Rajeev Garg*and GD Gupta
Department of Pharmaceutics and Pharmaceutical Technology ASBASJSM College of Pharmacy, Bela, Ropar- 140111, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009

 View HTML        View PDF

ABSTRACT:
The present study involves preparation and evaluation of floating microspheres of acyclovir as model drug for prolongation of gastric residence time. The microspheres were prepared by emulsion solvent evaporation method using polymers hydroxyl propyl methyl cellulose, ethyl cellulose, eudragit S100 and eudragit RL. The prepared floating microspheres were evaluated for flow properties by calculating the angle of repose, compressibility index and various physicochemical parameters including particle size, incorporation efficiency, in vitro floatability studies, in vitro drug release studies. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy. The mean particle size increased with increasing ethyl cellulose concentration and eudragit S 100 concentration in cellulose and eudragit microspheres respectively. The scanning electron microscopy confirms the hollow nature of microspheres with pores on the surface of floating microspheres, which imparts floating properties to the prepared floating microspheres. The mean particle size increased and the drug release rate decreased at higher polymer concentration. The prepared microspheres exhibited prolonged drug release 12 h and remained buoyant. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Microspheres were evaluated for drug release was found to follow Higuchi kinetics and the drug release mechanism was found Fickian type. The developed floating microspheres of acyclovir may be used in clinic for prolonged drug release in stomach for at least 12 hrs, thereby improving the bioavailability and patient compliance.


Keywords:

Cite this article:
Rajeev Garg, GD Gupta. Development and Characterization of Cellulose and Eudragit Gastroretentive Floating Microspheres of Acyclovir. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 101-105.


Recomonded Articles:

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

Design and Characterization of Valsartan Co-Crystals to Improve its Aqueous Solubility and Dissolution Behavior

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Formulation and Evaluation of Irbesartan nanosuspension for Dissolution Enhancement

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Formulation and Development of a “Pressurised Metered Dose Inhalation” beclomethasone 250 mcg.

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution

Author(s): Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel

DOI: 10.5958/0974-360X.2017.00189.5         Access: Open Access Read More

Formulation, Characterization and In-vitro Evaluation of Abacavir Sulphate Loaded Microspheres

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Formulation and Characterization of Taste Masked Rapid Disintegrating Tablets of Trimetazidine HCl

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Physical Rheological and Cell Viability Study of Some Selected Plant Polysaccharides

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Preparation, Physicochemical Characterization, Dissolution and Formulation Studies of Immediate release tablets of Amlodipine Besylate and Hydrochlorothiazide

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

A Review on Transbuccal Drug Delivery System and its Commercially Available Products

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Preparation and Evaluation of Ocular Inserts For Controlled Delivery of Ciprofloxacin Hydrochloride

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide

Author(s): Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra

DOI: Not Available         Access: Open Access Read More

Multilayer Tablet Technology – Options and Opportunities

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Isolation and Characterization of an actinomycete strain producing an antifungal metabolite effective against Candida albicans

Author(s): Adithya Chandrashekar, Anuraag Muralidharan, Ananthamurthy Koteshwara, Angel Treasa Alex, V. M. Subrahmanyam

DOI: 10.5958/0974-360X.2019.00791.1         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
Regulatory requirements for Post approval changes in Japan, Canada and Malaysia
Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats
Synthesis and Antibacterial activity of some newer Benzimidazole derivatives
The Correction Methods of the Intestinal Microflora in Chronic Colonic Stasis by Siphon Enema and Probiotics as a Means of the Hirschsprung-associated Enterocolitis Prevention
Stability Indicating HPTLC Determination of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations
Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats
In Vitro Antioxidant and Antibacterial Screening of flowers Extract from Cassia auriculata Linn.
Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method
Phytochemical assessment and Bioactivity of alcoholic extract seed of Louranthus europpaeus
Design, Development and Evaluation of Solid Form of Liquid Self-Nanoemulsifying Formulation for improving the Oral Bioavailability of Itraconazole
Optimization and Characterization of Exopolysaccharide from Marine Soil Bacteria
Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets
Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility
An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile
Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β- carbon
Pharmacognostical Evaluation and HPTLC Analysis of Two Medicinally important Secondary Metabolites in Bauhinia variegata Leaves from Gorakhpur District in Summer Season
Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil
Endoscopic Retrograde Cholangiopancreatography in Central Iraq: A Retrospective Single- Center Study
Biosynthesis of Gold Nanoparticles using Leaf Extract of Desmodium gangeticum and their Antioxidant Activity

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 5855
Yesterday: 14315
Total: 1756037