Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Development and Characterization of Cellulose and Eudragit Gastroretentive Floating Microspheres of Acyclovir

Author(s): Rajeev Garg, GD Gupta

Email(s): indianpharmacist@sify.com

DOI: Not Available

Address: Rajeev Garg*and GD Gupta
Department of Pharmaceutics and Pharmaceutical Technology ASBASJSM College of Pharmacy, Bela, Ropar- 140111, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009

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ABSTRACT:
The present study involves preparation and evaluation of floating microspheres of acyclovir as model drug for prolongation of gastric residence time. The microspheres were prepared by emulsion solvent evaporation method using polymers hydroxyl propyl methyl cellulose, ethyl cellulose, eudragit S100 and eudragit RL. The prepared floating microspheres were evaluated for flow properties by calculating the angle of repose, compressibility index and various physicochemical parameters including particle size, incorporation efficiency, in vitro floatability studies, in vitro drug release studies. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy. The mean particle size increased with increasing ethyl cellulose concentration and eudragit S 100 concentration in cellulose and eudragit microspheres respectively. The scanning electron microscopy confirms the hollow nature of microspheres with pores on the surface of floating microspheres, which imparts floating properties to the prepared floating microspheres. The mean particle size increased and the drug release rate decreased at higher polymer concentration. The prepared microspheres exhibited prolonged drug release 12 h and remained buoyant. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Microspheres were evaluated for drug release was found to follow Higuchi kinetics and the drug release mechanism was found Fickian type. The developed floating microspheres of acyclovir may be used in clinic for prolonged drug release in stomach for at least 12 hrs, thereby improving the bioavailability and patient compliance.


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Cite this article:
Rajeev Garg, GD Gupta. Development and Characterization of Cellulose and Eudragit Gastroretentive Floating Microspheres of Acyclovir. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 101-105.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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