Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium

Author(s): N Arunkumar, C Rani, KP Mohanraj

Email(s): mmcarun@gmail.com

DOI: Not Available

Address: N Arunkumar1*, C Rani1 and KP Mohanraj2
1Department of Pharmaceutics, Cherraan’s College of Pharmacy, Coimbatore.
2Department of Pharmaceutical Technology, Jadavpur University, Kolkatta.
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008

 View HTML        View PDF

ABSTRACT:
The present study was aimed at preparing a Floating drug delivery system for the model drug Atorvastatin calcium, and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies. Four formulations containing varying proportions of polymers like HPMC K4M and Ethyl cellulose and fixed amount of gas generating agent such as Sodium bi carbonate and hydrophobic meltable material like bees wax were prepared. The tablets were prepared by melt granulation technique and the prepared tablets remained buoyant for more than 8hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. All the formulations exhibited diffusion dominant drug release and were found to be stable.


Keywords:

Cite this article:
N Arunkumar, C Rani, KP Mohanraj. Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 492-495.

Cite(Electronic):
N Arunkumar, C Rani, KP Mohanraj. Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 492-495.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2008-1-4-99


Recomonded Articles:

Formulation and Evaluation of Sustained Release Matrix Tablets of Pregabalin

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

The Structure of Skin and Transdermal Drug Delivery System- A Review

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Sodium Alginate Microbeads of Carvedilol

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Sustained Release Matrix Tablets Using Natural Polymer as Release Modifier

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Formulation and Evaluation of Floating Drug Delivery System Using Losartan

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Formulation and in vitro evaluation of gastroretentive drug delivery systems of amoxicillin trihydrate

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Mathematical Modelling of Dissolution Kinetics in Dosage forms

Author(s): Mohamed Rizwan I, Damodharan N

DOI: 10.5958/0974-360X.2020.00247.4         Access: Open Access Read More

Formulation and Evaluation of Albumin Microspheres containing Stavudine

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Formulation of Sustained Release Matrix Tablets of Diclofenac Sodium Using New Hydrophilic Gum Blends

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

A Review on Floating Drug Delivery System of H2 Receptors

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

The Liquisolid Technique for Enhancement of Drug Dissolution

Author(s): Asija Rajesh, Patel Pinkesh, Asija Sangeeta

DOI: Not Available         Access: Open Access Read More

Design and Evaluation of Sustained Release Matrix Tablet of Metformin Hydrochloride

Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Oral Osmotic Tablets for Metoprolol Succinate.

Author(s): P.S. Salve

DOI: Not Available         Access: Open Access Read More

Multilayer Tablet Technology – Options and Opportunities

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Formulation and In-Vitro Evaluation of Simvastatin Floating Tablets by Direct Compression Method

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation Study of Azithromycin Tablets by Various Natural Polymers and their Comparative Preformulation Study

Author(s): Sunirmal Bhattacharjee, Gouranga Dutta, Nilayan Guha, Devdut Banerjee, Tathagarta Roy, Siddheswar Maiti

DOI: 10.5958/0974-360X.2018.00208.1         Access: Open Access Read More

Nano-novel approach: Self Nano Emulsifying Drug Delivery System (SNEDDS) - Review Article

Author(s): Akiladevi D, Hari Prakash, Biju Gb, Madumitha N

DOI: 10.5958/0974-360X.2020.00183.3         Access: Open Access Read More

Formulation and Evaluation of Effervescent Floating Tablet of Amlodipine besylate

Author(s): Pare A, Yadav SK, Patil UK

DOI:         Access: Open Access Read More

Dissolution Profiling of Bilayered Conventional Release Paracetamol and Sustained Release Ibuprofen (By Simultaneous Estimation Method UV)

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Development and Validation of RP-HPLC Method for the Estimation of Clomiphene Citrate in Pharmaceutical Dosage Form
Analytical Method Development and Validation of Etravirine by RP-UFLC
Starch Nanoparticles Preparation and Characterization by in situ combination of Sono-precipitation and Alkali hydrolysis under Ambient Temperature
Comparative effects of Venlafaxine and Alendronate on Biochemical, Bone mechanical and Anti-inflammatory properties in ovariectomized rats
Solid Dispersion Characteristics of Whiteleg Shrimp (Litopenaeus vannamei) Extracted Chitosan with HPMC and PVP K-30 as Anti-cholesterol Agents
Determination of Extractive Value, Phytochemical Constituents and In-Vitro Anti-Urolithiatic Activity of Embelia ribes Burm. F. and Ipomea Hederacea Jacq.
Special Emphasis on Bioanalytical Method Development and Validation of an Anti-Hypertensive Drug Azelnidipine by LC-ESI-MS/MS in Healthy Human Volunteer’s Blood Plasma
Molecular Docking Analysis of the T450A Mutation of the Gene rpoB Mycobacterium leprae from Leprosy Patients in Papua, West Papua and North Maluku, Indonesia
Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety
A Study to find the effectiveness of Scapular Strengthening Exercise in patients with Cervical Dysfunction
Investigation of Gonadal Function, Puberty, and their relationship to Serum Ferritin in Male patients with β-Thalassemia major in Syria
Investigation of Immunomodulatory Activity of Methanolic Extract and Isolated Compound of Pavonia odorata Roots in Mice
Antimicrobial activity of some Essential oils and Extracts from Natural sources on Skin and Soft tissue infection causing microbes: An In-vitro Study
Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate
Development of Dermatological Ointment based on Aloe arborescens juice
Determination of Thiamine Hydrochloride in Commonly used food Materials-Rice by UV-Spectrophotometric Methods
The effectiveness of Smartphone application-based education “Teman Diabetes” on clinical outcomes of Type-2 Diabetes mellitus patients
Solvodynamic study on Solubility Enhanced Lovastatin in presence of Arginine as Cosolute
Natural Approaches to Whiten the Dental Enamel Surface Versus the Conventional Approaches
Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 6688
Yesterday: 16116
Total: 8522587