Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium

Author(s): N Arunkumar, C Rani, KP Mohanraj

Email(s): mmcarun@gmail.com

DOI: Not Available

Address: N Arunkumar1*, C Rani1 and KP Mohanraj2
1Department of Pharmaceutics, Cherraan’s College of Pharmacy, Coimbatore.
2Department of Pharmaceutical Technology, Jadavpur University, Kolkatta.
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008

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ABSTRACT:
The present study was aimed at preparing a Floating drug delivery system for the model drug Atorvastatin calcium, and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies. Four formulations containing varying proportions of polymers like HPMC K4M and Ethyl cellulose and fixed amount of gas generating agent such as Sodium bi carbonate and hydrophobic meltable material like bees wax were prepared. The tablets were prepared by melt granulation technique and the prepared tablets remained buoyant for more than 8hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. All the formulations exhibited diffusion dominant drug release and were found to be stable.


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Cite this article:
N Arunkumar, C Rani, KP Mohanraj. Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 492-495.

Cite(Electronic):
N Arunkumar, C Rani, KP Mohanraj. Formulation and In Vitro evaluation of oral floating tablets of atorvastatin calcium. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 492-495.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2008-1-4-99


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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