Author(s): NM Bhopale, PB Aswar, NB Banarase, SS Khadabadi

Email(s): nileshbhopale@yahoo.co.in

DOI: Not Available

Address: NM Bhopale*, PB Aswar, NB Banarase and SS Khadabadi
Government College of Pharmacy, Amravati 444 604 (MS) India
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008


ABSTRACT:
The purpose of the present investigation was to develop the sustained release matrix tablet of Rubia cordifolia using the various polymers like HPMC (Hydroxy-Propyl-methyl-cellulose), Ethyl cellulose, of different viscosity grade. Tablet formulations were developed using wet granulation method. Water extract of Rubia cordifolia was used. Addition of different diluents like lactose, magnesium stearate and cab-o-sil were used for improving flowability and compressibility. Binder such as polyvinyl pyrrolidone was used for optimization of the formulations. Sodium starch glycolate was used as disintegrating agent. Pre and post formulation parameters were studied for all the batches. HPMC –KM4 shows better result for matrix tablet in terms of sustained drug release with comparison to different viscosity grade of HPMC and ethyl cellulose. The dissolution study, of the Rubia cordifolia tablets exhibited 99.54% release of total polyphenol.


Cite this article:
NM Bhopale, PB Aswar, NB Banarase, SS Khadabadi. Design, Development and In-vitro Evaluation of Sustain Release Rubia cordifolia Matrix Tablet. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 475-477.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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