The influence of irbesartan on the pharmacokinetics of gliclazide 3.7 mg/kg, p.o was studied in adult healthy albino rabbits, (n=5). All the animals were fasted for 18 hours prior to experimentation, during this period the animals were fed with water ad libitum. In the first phase, the pharmacokinetics of gliclazide 3.7 mg /kg, p.o was studied. After a washout period of one week the animals were used for second phase studies and were administered with irbesartan 14 mg/kg, p.o and gliclazide 3.7 mg/kg, p.o 30 minutes later. In the third phase, the animals were administered with Irbesartan 14 mg/kg, p.o for 7 consecutive days post second phase. On the 8th day of post second phase and 30 minutes after the irbesartan administration, gliclazide 3.7 mg/kg, p.o was administered. In all the three phases the blood samples were collected from the marginal ear vein at time intervals of 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 hours and the drug concentration was estimated using HPLC and the pharmacokinetic parameters were calculated. The study indicated that irbesartan pretreatment did not affect the pharmacokinetics of gliclazide.
Cite this article:
TE Gopala Krishna Murthy, C Mayuren. Pharmacokinetics of Gliclazide Alone and in Combination with Irbesartan in Rabbits. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 418-421.