Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Sustained Release Matrices of Verapamil HCl Using Glyceryl Monosterate and Stearic Acid

Author(s): Durgacharan A Bhagwat, Pravin S Kawtikwar, Dinesh M Sakarkar

Email(s): durgapharma@gmail.com

DOI: Not Available

Address: Durgacharan A Bhagwat*, Pravin S Kawtikwar and Dinesh M Sakarkar
Dept. of Industrial Pharmacy, S. N. Institute of Pharmacy, Pusad. Dist: Yavatmal. 445 204. M.S. India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008

 View HTML        View PDF

ABSTRACT:
Glyceryl monostearate and Stearic acid are waxy materials can be used in formulation of sustained release dosage form of water soluble drugs. It was decided to study the effect of these waxes at different drug: wax ratios, on the release profile of drug from matrix formulations prepared using Glyceryl monostearate, Stearic acid and both waxes in combination. Because of the high frequency of administration and short biological half-life, Verapamil HCl was considered as an ideal drug for designing sustained release formulation. The sustained release matrices of Verapamil HCl were prepared by melt granulation technique in different drug: wax ratios. Drug release was studied by using USP apparatus-I with pH 1.2 for one hour and pH 6.8 for seven hours. The drug release profile compared with marketed formulation and specifications given in USP for extended release Verapamil HCl tablets. During dissolution study different parameters such as effect of different drug: wax ratio and combination of waxes and effect of release enhancers such as MCC and Lactose were studied. The results of dissolution study showed that release of drug from matrices prepared from combination of both waxes gets more retarded than from Glyceryl monostearate and Stearic acid alone. Also study revealed that as concentration of waxes increases, release of drug from matrices decreases. Effect of release enhancers showed that use of lactose produces a higher release of drug compared to MCC. Dissolution of Verapamil HCl from matrices followed first order and Higuchi’s square root kinetic model.


Keywords:

Cite this article:
Durgacharan A Bhagwat, Pravin S Kawtikwar, Dinesh M Sakarkar. Sustained Release Matrices of Verapamil HCl Using Glyceryl Monosterate and Stearic Acid. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 405-409.


Recomonded Articles:

Screening Methods for Hepatoprotective Agents in Experimental Animals

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

A Prospective Study on Drug Utilization Evaluation of Antibiotics for Surgical Prophylaxis

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

A Prospective Study of Drug Utilization and Evaluation of Gastro Intestinal Agents

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Comparative Evaluation of Quality Control Parameters of Marketed Antidiabetic Tablet

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Formulation Development and Characterization of Etodolac Loaded Transethosomes for Transdermal Delivery

Author(s): S. B. Gondkar, Neha R. Patil, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00541.8         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets of Pregabalin

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Formulation and Characterization of Taste Masked Rapid Disintegrating Tablets of Trimetazidine HCl

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

The Structure of Skin and Transdermal Drug Delivery System- A Review

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague –Dawley Rat Model

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Effect of Chemical Enhancers on in-vitro Permeation of Losartan Potassium

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Approaches and Challenges of Protein and Peptide Drug Delivery Systems

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Preparation and Evaluation of Ocular Inserts For Controlled Delivery of Ciprofloxacin Hydrochloride

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Magnetic Nanoparticles: As a Drug Targeting Carrier

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Multilayer Tablet Technology – Options and Opportunities

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Carriers used for the development of solid dispersion for poorly water-soluble drugs

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Taste Masking: A Review

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



The Study of the Chemical composition of Sorption Substances
Serum level of Periostin Among Adult Asthmatic Patients
Development, Characterization and In vitro Evaluation of Donepezil solid Lipid Nanoparticles
Methylene Blue Degradation by AgCuO Bimetallic Nanomaterial, Green Synthesized using Cordia sebestena leaves
Structure-based Pharmacophore Modelling for identifying VEGFR2 Inhibitor
In silico molecular docking of Vetiver oil and formulation of Vetiver oil-Encapsulated gellan gum-based Microcapsules for Antidepressant activity
Impact of Processing on Inulin and sugars content of Jerusalem Artichoke Tuber
Studies on the Anti-inflammatory potential of selected medicinal plants in vitro
Study of Anticoagulants low molecular weight heparin and Unfractionated heparin in the management of Non-St elevation Myocardial Infarction
Synthesis, Characterization and Anti-oxidant Activity of some Novel Pyrazoline derivatives
Renoprotective effect of Corallocarpus epigaea in Nephropathy in Wistar Rats
Prevalence of antibiotic resistance and biofilm formation in Klebsiella pneumoniae carrying fimbrial genes in Egypt
Identification of Bioactive Compounds in the leaves extract of Piper longum using GCMS
Studying Some Novel Biochemical and Immunological Markers in a Sample of Iraqi Women with Polycystic Ovarian Syndrome
Comparative Studies on Total Polyphenols, Flavanoids and Antioxidant Potential ofsome Marketedbrands of packed Green Tea
Formulation and Evaluation of Oral Dispersion Tablet of Telmisartan
The Evaluation of Clinical Pharmacy services Performance at Community Health centers of sebatik island regency of Nunukan province of north Kalimantan (Indonesia-Malaysia Border)
Detection of Novel apyrimidinic Endonuclease 1 (APE1) in a sample of Iraqi cervical cancer patients using Immunohistochemistry Technique
Analgesic activity of Annona squamosa Linn fruit peels on Swis Albino mice
Heavy metal accumulation by earthworm Eisenia fetida from animal waste, soil and wheat (Triticum aestivum) for protection of human health

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 12781
Yesterday: 17108
Total: 2123528