ABSTRACT:
This article investigates enhancement of the dissolution profile of furosemide using solid dispersion (SD) with crospovidone (CPV) by using kneading technique. 1:1 (w/w) and 1:2 (w/w) solid dispersions were prepared by kneading method using solvent water and ethanol in 1:1 ratio. Dissolution studies using the USP paddle method were performed for solid dispersions of furosemide at 37 ± 0.5oC and 50 rpm in simulated gastric fluid (SGF) of pH 1.2. Fourier transformer infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with commercial products. IR spectroscopy, XRD, and DSC showed change in the crystal structure towards amorphous one of furosemide (FRMD). Dissolution of furosemide improved significantly in solid dispersion the 1:2 solid dispersion indicated increase in dissolution 5.11 fold. Tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of furosemide.