PA Patel, GM Chaulang, A Akolkotkar, SS Mutha, SR Hardikar, AV Bhosale
PA Patel*, GM Chaulang , A Akolkotkar, SS Mutha, SR Hardikar and AV Bhosale
Department of Pharmaceutics, SGRS College of Pharmacy, Saswad, Pune (MS), India. PIN – 412301
Volume - 1,
Issue - 4,
Year - 2008
Oral route still remains the favorite route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bio-availability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variability, lack of dose proportionality and therapeutic failure. It is estimated that 40% of active substances are poorly soluble in water. The improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. Various technological strategies are reported in the literature including micronization, solid dispersions or cyclodextrines complex formation and different technologies of drug delivery systems. Among various approach self-emulsifying drug delivery system has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT, and protection of drug(s) from the hostile environment in gut.
Cite this article:
PA Patel, GM Chaulang , A Akolkotkar, SS Mutha, SR Hardikar, AV Bhosale. Self Emulsifying Drug Delivery System: A Review. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 313-323.