Author(s): John I D’souza, Harinath N More

Email(s): johnsir4u@gmail.com

DOI: Not Available

Address: John I D’souza*and Harinath N More
Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur 416 013, M.S., India
*Corresponding Author

Published In:   Volume - 1,      Issue - 4,     Year - 2008


ABSTRACT:
Fluocinolone acetonide (FA) is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. The percutaneous absorption increases risk associated with systemic absorption of topically applied formulation. Controlled release of drug to the skin could reduce the side effect while reducing percutaneous absorption. Therefore, the aim of the present study was to produce FA entrapped microporous microparticles (microsponges) to control the release of drug to the skin. Microsponges were prepared by previously optimized quasi-emulsion solvent diffusion method. Compatibility of drug with reaction adjuncts was studied by FT-IR and DSC. Production yield, loading efficiency and particle size analysis and surface morphology of microsponges were performed. Microparticles were then carbopol 934 gels into standard vehicles for release and comparative anti-inflammatory studies. Free flowing powder microsponges were spherical in shape, between 31.34 and 82.26 µm in diameter. FT-IR and DSC studies revealed absence of primary incompatibility between formulation adjuvants and process parameters. Surface morphology by scanning electron microscopy revealed micro-porous nature of microsponges. Drug release was observed controlled with comparative anti-inflammatory activity with the gels containing free drug.


Cite this article:
John I D’souza, Harinath N More. Topical Anti-Inflammatory Gels of Fluocinolone Acetonide Entrapped in Eudragit Based Microsponge Delivery System. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 502-506.


Recomonded Articles:

Author(s): P. Geetha, M. Kousalya, S. Geetha Lakshmi, R. Gopi.

DOI: 10.5958/0974-360X.2016.00046.9         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Suresh V Kulkarni, Ranjit Kumar P, Nikunj Patel, Ramesh B, Someshwara Rao B, Ashok Kumar P

DOI: Not Available         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Soumya Khare, Amit Alexander, Ajazuddin, Nisha Amit

DOI: Not Available         Access: Open Access Read More

Author(s): Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags