Author(s): N Jawahar, R Sureshkumar, D Nagasamy Venkatesh, GNK Ganesh, S Jubie, MK Samanta, B Suresh

Email(s): jajupharma@yahoo.co.in

DOI: Not Available

Address: N Jawahar*, R Sureshkumar, D Nagasamy Venkatesh, GNK Ganesh, S Jubie, MK Samanta and B Suresh
Department of Pharmaceutics, J.S.S College of Pharmacy Rockland, ooty-643001 Tamil Nadu India
* Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008


ABSTRACT:
Nitrendipine an anti hypertensive drug which is practically insoluble in water. But water insolubility and the less bioavailability are the limitations of its effective use clinically. The present investigation aims to study the effect of various solvent on the modifications of Nitrendipine. The different forms of crystals were prepared by using various solvents such as acetone, benzene, methanol and blends of methanol with polyvinyl pyrrollidone (PVP- K30) and polyethylene glycol(PEG-4000).The prepared crystals were characterized by different physico-chemical techniques such as melting point, solubility, spectroscopic analysis and dissolution .The results indicate that the crystals obtained from different solvents exhibited different physiochemical characters .In conclusion ,the crystals prepared from benzene, PVP- K30 and PEG-4000 shows higher dissolution rate would result in an improved bio-availability


Cite this article:
N Jawahar, R Sureshkumar, D Nagasamy Venkatesh, GNK Ganesh, S Jubie, MK Samanta, B Suresh. Polymorphism: A Dissolution Rate Enhancement Technique of Nitrendipine. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 285-286.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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