Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Comparative Evaluation of Matrix Tablet of Diclofenac Sodium Employing Wet Granulation and Direct Compression Method Using Blend of Polymers

Author(s): Aisha Khanum, Gayathri Devi S

Email(s): aishakhanum@rediffmail.com

DOI: Not Available

Address: Aisha Khanum* and Gayathri Devi S
Al-Ameen College of Pharmacy, Hosur road Bangalore-27
* Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008

 View HTML        View PDF

ABSTRACT:
Matrix tablets Diclofenac sodium were formulated consisting of polymers such as polyethylene oxide (PEO) Mw 900,000 and sodium alginate in combination with different ratios by direct compression and wet granulation method with an aim to attain zero order release after the initial burst release and compare the of release kinetics of the drug from matrices prepared from wet granulation and direct compression method. Preformulation studies were carried out to investigate drug polymer interaction. This was done by carrying out Differential scanning calorimetry (DSC). FTIR spectra revealed that there was no shift in the peaks for pure drug and the selected polymers in the formulation indicating that there was no interaction between drug and the polymers. Matrix tablets were subjected to in-vitro drug release in 0.1N HCl pH 1.2 for 2 hrs followed by phosphate buffer pH 7.4 for remaining hours. In-vitro dissolution kinetics followed zero order drug release from (F6) formulation containing (drug: 30% PEO: 30% sodium alginate) which may be due to constant diffusional path length. Analysis of variance showed a significant difference (p>0.05) in drug release among the formulations. SEM study confirmed both diffusion and erosion mechanisms to be operative during drug release from the optimized batch of matrix tablet. Thus best formulation F6 (DC) prepared by direct compression exhibited almost similar drug release profile in different dissolution media as that of the marketed product F7 and prolonged the release for more than 10 hrs. The obtained best formulation showed good stability and satisfactory preclinical anti-inflammatory activity. Therefore the blend of hydrogels in appropriate proportions can release the drug for prolonged period of time. Hence polymer blend of PEO and sodium alginate are ideal for formulating controlled release, cost effective matrix tablets.


Keywords:

Cite this article:
Aisha Khanum, Gayathri Devi S. Comparative Evaluation of Matrix Tablet of Diclofenac Sodium Employing Wet Granulation and Direct Compression Method Using Blend of Polymers. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 265-269.


Recomonded Articles:

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Irbesartan nanosuspension for Dissolution Enhancement

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

To study Anti-inflammatory activity of 70% Methanolic Extract of Triumfetta rhomboidea : In Vitro Study

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Formulation and Evaluation of Diclofenac gel

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Formulation and Development of a “Pressurised Metered Dose Inhalation” beclomethasone 250 mcg.

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Diclofenac sodium Organogel

Author(s): Bhagyashree Purohit, Naveen Gupta, Shailesh Jain

DOI: Not Available         Access: Open Access Read More

Plants having Anti-arthritic and Immunomodulator Potentials: An Review

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Formulation Development and Evaluation of Silymarin Gel

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives

Author(s): K. Ishwar Bhat, Abhishek Kumar

DOI: 10.5958/0974-360X.2017.00190.1         Access: Open Access Read More

Anti-Inflammatory Activity of Abutilon indicum Linn. Leaf

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Mucoadhesive Buccal Tablets of Sumatriptan Succinate using Natural Gums

Author(s): Saleem M.A., Sudhir S. Pange, Shaikh Ahnaf Umair, Vishal Kumar Singh

DOI: Not Available         Access: Open Access Read More

An Overview of Miracle Enzyme- Serratiopeptidase

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Formulation and Evaluation of Dispersible Tablets of Sudarshan, Vyswanara and Panchasakar Churnas

Author(s): Mettu Srikanth Reddy, Mallikarjun Setty

DOI: Not Available         Access: Open Access Read More

CNS Depressant and Analgesic Activities of Different Extracts of Tephrosia purpurea Root

Author(s): 1Valli G., Vasanthi A., Vijayalakshmi R., Thanga Thirupathi A

DOI: Not Available         Access: Open Access Read More

Formulation of Sustained Release Matrix Tablets of Diclofenac Sodium Using New Hydrophilic Gum Blends

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

Microwave Assisted Synthesis of Fluoro-Pyrazole Derivatives for Antiinflammatory Activity.

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Aceclofenac Extended Release Matrix Tablets: Formulation and In Vitro Evaluation

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Biomedical Applications of Nanobiotechnology for Drug Design, Delivery and Diagnostics

Author(s): Soumya Khare, Amit Alexander, Ajazuddin, Nisha Amit

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Mucoadhesive Buccal Tablet of Simvastatin

Author(s): Ashish Jayant Saraf, Sudhir Pange, Satyajit Deshmukh, Rahul Hajgude

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
Regulatory requirements for Post approval changes in Japan, Canada and Malaysia
Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats
Synthesis and Antibacterial activity of some newer Benzimidazole derivatives
The Correction Methods of the Intestinal Microflora in Chronic Colonic Stasis by Siphon Enema and Probiotics as a Means of the Hirschsprung-associated Enterocolitis Prevention
Stability Indicating HPTLC Determination of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations
Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats
In Vitro Antioxidant and Antibacterial Screening of flowers Extract from Cassia auriculata Linn.
Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method
Phytochemical assessment and Bioactivity of alcoholic extract seed of Louranthus europpaeus
Design, Development and Evaluation of Solid Form of Liquid Self-Nanoemulsifying Formulation for improving the Oral Bioavailability of Itraconazole
Optimization and Characterization of Exopolysaccharide from Marine Soil Bacteria
Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets
Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility
An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile
Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β- carbon
Pharmacognostical Evaluation and HPTLC Analysis of Two Medicinally important Secondary Metabolites in Bauhinia variegata Leaves from Gorakhpur District in Summer Season
Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil
Endoscopic Retrograde Cholangiopancreatography in Central Iraq: A Retrospective Single- Center Study
Biosynthesis of Gold Nanoparticles using Leaf Extract of Desmodium gangeticum and their Antioxidant Activity

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 3200
Yesterday: 10367
Total: 1598665