Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants

Shailesh Sharma; Sudhir Bharadwaj; G. D. Gupta

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants

Author(s): Shailesh Sharma, Sudhir Bharadwaj, G. D. Gupta

Email(s): shaileshsharma_bela@yahoo.co.in

DOI: Not Available

Address: Shailesh Sharma*, Sudhir Bharadwaj and G. D. Gupta
Pharmaceutics Research Laboratory, Dept. of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Ropar) Punjab, 140111 India
.* Corresponding Author

Published In: Volume - 1, Issue - 3, Year - 2008

View HTML

View PDF

ABSTRACT:
In the present study comparisons of natural and synthetic superdisintegrants were performed. Various parts of Plantago ovata such as seed powder, husk powder and isolated mucilage were prepared and used as superdisintegrants in different concentrations. Their disintegrating and physiochemical properties were evaluated and compared with synthetic superdisintegrant crospovidone. The Fast Dissolving Tablets (FDT) of promethazine theoclate (as model drug) was prepared by direct compression method using microcrystalline cellulose and sucrose as direct compressible vehicle. These tablets were evaluated for quality control tests like organoleptic characteristics, weight variation, hardness, friability, in- vitro and in-vivo disintegration time, in-vitro swelling time, drug content and dissolution behavior. Swelling index was also investigated with an aim to compare the swelling property of seed powder, husk powder, mucilage of Plantago ovata with crospovidone. Among all the superdisintegrants, Plantago ovata mucilage showed the highest swelling index. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) showed similar disintegrating property than the most widely used synthetic superdisintegrants in the formulations of FDT.

Keywords:

Cite this article:
Shailesh Sharma, Sudhir Bharadwaj, G. D. Gupta. Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 218-224.

Cite(Electronic):
Shailesh Sharma, Sudhir Bharadwaj, G. D. Gupta. Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 218-224. Available on: https://rjptonline.org/AbstractView.aspx?PID=2008-1-3-58

Recomonded Articles:

Dental Waxes–A Review

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5 Access: Open Access Read More

Prevalence of Kwashiorkor, Marasmus, Marasmic Kwashiorkor and Age wise Distribution of Malnourished Tribal Children of Town Dhadgaon, District-Nandurbar of Maharashtra State, India.

Author(s): Sangeeta Pingale, V.W. Patil , Mukesh Hire , Anita Katkade

DOI: Not Available Access: Open Access Read More

Formulation of PLGA Polymeric Nanosuspension containing Pramipexole Dihydrochloride for improved treatment of Parkinson’s Diseases

Author(s): I. Somasundaram, B.V. Nagarjuna Yadav, S. Sathesh Kumar

DOI: 10.5958/0974-360X.2016.00155.4 Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets of Pregabalin

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available Access: Open Access Read More

In-vitro cell line Models and Assay methods to study the Anti-diabetic Activity

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6 Access: Open Access Read More

Qualitative Phytochemical Screening and In-vitro Anthelmintic Activity of Adhatoda vasica (Acanthaceae)

Author(s): Shabi Ruskin, R., S. Ajina

DOI: 10.5958/0974-360X.2017.00083.X Access: Open Access Read More

Assessment of Water Quality and Pollution of Porur, Chembarambakkam and Puzhal Lake

Author(s): R. Pradeep Kumar,Preethi. R

DOI: 10.5958/0974-360X.2017.00380.8 Access: Open Access Read More

Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available Access: Open Access Read More

Ocular Drug Delivery System – An Update Review

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8 Access: Open Access Read More

Study of Leachate Characterization in Landfill by Municipal Solid Waste

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6 Access: Open Access Read More

Phytochemical Analysis and Antimicrobial Activity of Ethonolic Leaf Extract of Ficus racemosa Linn

Author(s): T. Thilagavathi, G. Kathiravan

DOI: 10.5958/0974-360X.2017.00107.X Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0 Access: Open Access Read More