Author(s): R Siva Kumar, MR Santhanakrishnan, P Kumar Nallasivan, R Venkatanarayanan

Email(s): andrilan@rediffmail.com

DOI: Not Available

Address: R Siva Kumar*, MR Santhanakrishnan, P Kumar Nallasivan and R Venkatanarayanan
Dept. Pharma. Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore- 641 402. Tamilnadu, India.
* Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008


ABSTRACT:
A simple, specific, accurate, precise, rapid and reproducible reverse HPLC method has been developed for the simultaneous estimation of ezetimibe and simvastatin in bulk and tablet dosage forms using C18 column (symmetry, 4.6 mm x 25 cm) in isocratic mode with methanol: water (95:05 v/v) as a mobile phase with the detection wavelength of 248 nm and the flow rate was 0.8 ml/ min. The retention time of ezetimibe and simvastatin was found to 3.2 min and be 4.9 min, respectively. Linearity of the ezetimibe and simvastatin was found in the range of 5-70 µ g/ml and 5 - 50 µ g/ml, respectively. The recoveries of ezetimibe and simvastatin were found to be in the range of 99.27-101.10% and 99.63- 100.50%, respectively. The proposed method was validated suitably and can be used for routine analysis.


Cite this article:
R Siva Kumar, MR Santhanakrishnan, P Kumar Nallasivan, R Venkatanarayanan. Simultaneous RP-HPLC Method for Estimation of Ezetimibe and Simvastatin in Bulk and Dosage Forms. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 211-214.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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