Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Preparation and Evaluation of Mucilage of Ocimum Basilicum as a Gelling Agent.

Author(s): Shete AS, Mohite VL, Yadav AV

Email(s): amol.shete@rediffmail.com

DOI: Not Available

Address: Shete AS, Mohite VL and Yadav AV*
Dept. Biopharmaceutics ,Govt. College of Pharmacy, Karad, Dist.- Satara 415124 (MS) India.
* Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008

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ABSTRACT:
Mucilage from the seeds of Ocimum basilicum (family- labiatae) was separated by centrifugation. Physical characteristics of mucilage such as solubility, swelling index, loss on drying, pH, viscosity were studied. Diclofenac sodium was used as model drug for the formulation of gels and its compatibility with mucilage was proved by FTIR spectroscopy. Hydrogels were formulated with mucilage concentration ranging from 0.5 to 1.5 % and glycerin 30% as plasticizer. Evaluation of spredability parameter suggests the satisfactory rheological behavior of prepared hydrogels. Anti-inflammatory activity of prepared formulations was studied on carageenan induced rat hind paw edema model. The anti-inflammatory activity of prepared formulation was almost identical to that of marketed formulation. In vitro permeation across egg membrane was studied. The gels prepared with 0.75 and 1% of mucilage showed better release and spreadability characteristics. Stability studies of prepared hydrogels at room temperature indicate that they are quite stable.


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Cite this article:
Shete AS, Mohite VL, Yadav AV. Preparation and Evaluation of Mucilage of Ocimum Basilicum as a Gelling Agent. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 201-203.

Cite(Electronic):
Shete AS, Mohite VL, Yadav AV. Preparation and Evaluation of Mucilage of Ocimum Basilicum as a Gelling Agent. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 201-203.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2008-1-3-53


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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