Author(s): Kevin C Garala, Romal J Garala, Harinath N More, Anil J Shinde

Email(s): ajshinde07@rediffmail.com

DOI: Not Available

Address: Kevin C Garala1, Romal J Garala2, Harinath N More1 and Anil J Shinde1*. 1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-413016, Maharashtra, India.
2Department of Pharmaceutics, Padm. Dr.DY.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Maharashtra, India.
* Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008


ABSTRACT:
The present work was designed to develop suitable transdermal matrix patches of Tramadol hydrochloride, a non- steroidal anti-inflammatory drug, using hydroxy propyl methyl cellulose (HPMC) and Eudragit RS 100 with triethyl citrate as a plasticizer in group A and in group B, other than HPMC and Eudragit RS 100, cross-linking agent, succinic acid was added. A 32 full factorial design was employed for both groups. The concentration of HPMC and Eudragit RS- 100 were used as independent variables, while percentage drug release was selected as dependent variable. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 µ ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at ? max 272 nm. The experimental results shows that the patch containing HPMC in higher proportion gives increase in the release of drug and patches containing cross linking agent shows more release than those do not contains succinic acid.


Cite this article:
Kevin C Garala, Romal J Garala, Harinath N More, Anil J Shinde. Effect of Cross-linking Agent on the Release of Drug from the Transdermal Matrix Patches of Tramadol Hydrochloride. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 187-192.


Recomonded Articles:

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mostafa Isbera, Ayat Abbood, Wehad Ibrahim

DOI: 10.5958/0974-360X.2016.00039.1         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Kumaraswamy G., J.M. Rajendrakumar, J.V.L.N. Sheshagirirao, U. Ashok Kumar, M. Arunadevi

DOI: Not Available         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): Soumya Khare, Amit Alexander, Ajazuddin, Nisha Amit

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags