Author(s): YS Gattani, PS Kawtikwar, DM Sakarkar

Email(s): ygattani@gmail.com

DOI: Not Available

Address: YS Gattani*, PS Kawtikwar and DM Sakarkar
Department of Industrial Pharmacy, S. N. Institute of pharmacy, Pusad. Dist: Yavatmal 445 204
*Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2008


ABSTRACT:
Floating drug delivery system (microsphere) promises to be a potential approach for gastric retention. The present study was designed to formulate floating microsphere of tramadol hydrochloride by using enteric polymer such as acrycoat S 100 to improve the release profile of the drug and also target it to stomach and upper intestine via gastric retention. The microspheres were prepared by non-aqueous emulsification solvent evaporation technique. A 32 factorial design was used to elucidate the effect of variable viz. amount of drug and the amount of polymer. Non-aqueous emulsification solvent evaporation technique resulted in floating microsphere with good yield and moderate entrapment. The prepared floating microsphere sizes were in the range of 241.12 ± 8.4 to 421.42 ± 12.4 µm. These floating microspheres of tramadol hydrochloride were capable of floating on simulated gastric fluid for more than 12 hour. The amount of polymer affected the particle size and drug release. As the polymer concentration increases the particle size increases and drug release decreases.


Cite this article:
YS Gattani, PS Kawtikwar, DM Sakarkar. Preparation and Evaluation of Tramadol Hydrochloride Floating Oral Delivery System. Research J. Pharm. and Tech. 1(3): July-Sept.. 2008;Page 171-174.


Recomonded Articles:

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Alai M.S., Shinkar D.M., Saudagar R.B.

DOI: 10.5958/0974-360X.2017.00646.1         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): Samiksha Warke, Prashant Warke, M.K. Kale, Vipin Saini

DOI: Not Available         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Shinde AD, Bhise SB

DOI: Not Available         Access: Open Access Read More

Author(s): Venkateswaramurthy N, Sambathkumar R, Vijayabaskaran M, Perumal P

DOI: Not Available         Access: Open Access Read More

Author(s): B Chengaiah, M Alagusundaram, S Ramkanth, C Madhusudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): Nighute AB, Bhise SB

DOI:         Access: Open Access Read More

Author(s): Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Kute Chaitrali, Dev Asish, Rathod Sudha, Qureshi Altamash

DOI: Not Available         Access: Open Access Read More

Author(s): Veeranagoud Biradar, Jeevan Matada Basavarajaiah, Myat Thu Thu Win, Leneena Gudugunta, Suresh KV , Sathiyavathi Mahendra Kumar, Neeraja Turagam, Lavanya Priya

DOI: 10.5958/0974-360X.2019.00622.X         Access: Open Access Read More

Author(s): Sudha Rathod, Tejaswi R. Kale, Deepali A. Shewale, Praveen N. Lohar

DOI: Not Available         Access: Open Access Read More

Author(s): Radhika PR, Luqman Moidutty, Borkhataria Chetan H

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags