Author(s): Karthikeyan D., Sonkar S., Pandey V.P., Nandha kumar J., Sengottuvelu S., Bhowmick M., Shivakumar T.

Email(s): karthii69@yahoo.co.in

DOI: Not Available

Address: Karthikeyan D.*1, Sonkar S.1, Pandey V.P.2, Nandha kumar J.1, Sengottuvelu S.1, Bhowmick M.1, Shivakumar T.1
1Nandha College of Pharmacy, Erode-638052, Tamil Nadu, India.
2Department of Pharmacy, Faculty of Science and Technology, Annamalai University, Chitambaram, India.
* Corresponding Author

Published In:   Volume - 1,      Issue - 2,     Year - 2008


ABSTRACT:
The objective of the present work is to develop modified ocular inserts of Indomethacin having a single film instead of tri-film and evaluate its potential for sustained ocular delivery. The advantage of having a single film is that it considerably reduces the thickness and weight of ocular insert as well as is better retained in the cul-de-sac of the eye. The modified ocular insert was prepared by solvent casting method using polymers Eudragit RS 100 (ERS) and Ethyl cellulose (EC). Dichloromethane (DCM) and Dibutyl phthalate (DBP) were used as solvent and plasticizer respectively. The modified ocular inserts were evaluated for drug-excipient interaction, physico-chemical characteristics, stability studies, sterility studies, ocular irritation test, in-vitro and in-vivo release studies. Attenuated total reflectance Fourier Transform Infra-red spectroscopy (ATR-FTIR) was used to study the interaction between drug and excipients, which enable the modified ocular insert to be examined directly without further preparation (in contrast to KBr method). The in-vitro release study of the formulations follow zero order kinetics and revealed that the drug released by super case II kinetics (n>1). The optimized formulation F7, when inserted into the eye of rabbit showed controlled release upto 24 hours. There was a good correlation between in-vitro and in-vivo release data. On the basis of above studies, it can be concluded that the modified ocular insert having a single film provided the desired drug release for 24 hours and remained stable and intact at ambient conditions.


Cite this article:
Karthikeyan D., Sonkar S., Pandey V.P., Nandha kumar J., Sengottuvelu S., Bhowmick M., Shivakumar T.. Development and Characterization of Modified Ocular Inserts with Improved Ocular Compatibility. Research J. Pharm. and Tech. 1(2): April-June. 2008;Page 93-99.


Recomonded Articles:

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Nur Qistina Binti Ahmad Fauzi, Vishnupriya V, Gayathri R.

DOI: 10.5958/0974-360X.2016.00240.7         Access: Open Access Read More

Author(s): Oruganti Sai Koushik, V. Himaja, P. Srinivasa Babu, Ramadoss Karthikeyan

DOI: 10.5958/0974-360X.2015.00298.X         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags