Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

Email(s): karthii69@yahoo.co.in

DOI: Not Available

Address: Karthikeyan D, 1* Vijayakumar S, 1 Pandey V.P, 2Nandha Kumar J, 1 Sengottuvelu S, 1 and T. Sivakumar T. 1
¹Department of Pharmaceutics, Nandha College of Pharmacy Perundurai main road, Erode-52, Tamilnadu, India.
2Department of Pharmacy, Annamalai University, Chidambaram, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 1,     Year - 2008


ABSTRACT:
Topical administration of drug to treat ocular diseases is accomplished primarily by means of solutions, ointments, and suspensions. These are relatively inefficient as drug delivery systems often only 1% of the available drug is absorbed by the eye. Ciprofloxacin hydrochloride is a fluroquinolone anti-bacterial drug effective in the treatment of bacterial infections. Ciprofloxacin hydrochloride ocuserts were prepared using different polymers in various proportions. The in-vitro release of the drug from the formulations was studied using a commercial semipermeable membrane. The objective of the present work was to prepare ocular inserts with the target of increasing the contact time, reducing the frequency of administration, improving patient compliance and greater therapeutic efficacy. Ocular inserts were prepared by solvent casting technique using different polymers such as polyvinyl alcohol alone (4 %, 5 %, 6 %) and polyvinyl alcohol with polyvinyl pyrrolidone K-30, (4:0.5, 4:1, 4:1.5, 4:2, 4:2.5, 4:3) as a drug reservoir and ethyl cellulose (4 %) as a rate controlling membrane. Ocular inserts were evaluated for their physicochemical parameters like thickness, weight uniformity, drug content, percent moisture loss, and percent moisture absorption. The in-vitro drug release studies were carried out using Bi-chambered donar, receptor compartment model. Since targeted prolong release was observed in formulation F-7. The optimized formulation F-7 was subjected to in-vivo drug release study using rabbits as an animal model, Sterility testing and accelerated stability studies to access the effectiveness of the formulation. In-vitro drug release kinetic data was treated according to Higuchi and Peppas kinetics to access the mechanism of drug release. It can be concluded that the formulation F-7 provided the desired drug release for 24 hrs and remained stable and intact at ambient conditions. The results indicated a good correlation between in-vitro and in-vivo studies.


Cite this article:
Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T. . Preparation and Evaluation of Ocular Inserts For Controlled Delivery of Ciprofloxacin Hydrochloride. Research J. Pharm. and Tech. 1(1): Jan.-Mar. 2008; Page 40-45.


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Author(s): Adithya Chandrashekar, Anuraag Muralidharan, Ananthamurthy Koteshwara, Angel Treasa Alex, V. M. Subrahmanyam

DOI: 10.5958/0974-360X.2019.00791.1         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags