INTRODUCTION:

Sansevieria (snake plants) is a genus of 70 herbaceous, perennial native to Africa, India and Southeast Asia and are popular indoor and outdoor attractive succulents^1,2,3. It is a genus of xerophytic, rhizomatous, evergreen perennials which are recognized as ornamental plants with antioxidant potential and provides protection against environmental free radicals^4,5 Traditionally, fibers found in the leaves may be used to make mats, rope, cordage, caps, bowstrings, and apparel, hence these are highly coveted.

Among the medical disorders, a leaf concoction can be used to treat wounds, ulcers, haemorrhoids, earaches, stomachaches, toothaches, and intestinal worms^6,7 Snake plants also have a strong potential to minimize environmental pollution caused by gases and heavy metals. For instance, having two Sansevieria trifasciata plants in an office can lower CO₂concentrations by up to 19%^8,9 Snake plants can safely eliminate volatile chemical contaminants such as formaldehyde, acetone, benzene, and xylene from indoor air^10-18 In-depth descriptions of anticancer and folkloric uses of Sansevierian succulents such as Sansevieria liberica Gerome and Labroy, Sansevieria roxburghiana Schult. and Schult. F, Sansevieria masoniana C, Sansevieria trifasciata Prain, Sansevieria suffruticosa N.E.Br have been researched in this review article.

1. Sansevieria liberica Gérome and Labroy :

This perennial plant, known as "mother-in-law's tongue," has a range of traditional uses, including the treatment of asthma, ulcers, snake bites, and malaria^19,20,21,22. Phytochemical analysis reveals the presence of flavonoids, saponins, and carotenoids. Cytotoxic studies using SRB and in vivo models (Sarcoma-180) suggest anticancer potential^23-31. Its antioxidant properties further align with its folkloric applications^32,33.

2. Sansevieria roxburghiana Schult. and Schult. F^34-39:

Known as "Indian bowstring hemp," this herb is widely distributed in India and Southeast Asia. Traditionally used as a cardiotonic and to treat rheumatism, coughs, and snake bites, it contains alkaloids, flavonoids, and tannins^,40-47. Cytotoxic effects have been observed against K562 leukemia and SGC-7901 gastric cancer cell lines^48-54. Its hydroalcoholic extract significantly reduced tumor volume in mice and restored antioxidant enzyme levels^55-62.

3. Sansevieria masoniana C:^{36, 63, 64,65}

This rhizomatous succulent, commonly known as "whale’s fin," is valued for air purification. Its phytochemical profile includes flavonoids and saponins, which exhibit anticancer properties by activating apoptotic pathways and reversing multidrug resistance^66-69. Brine shrimp lethality tests demonstrated potential anticancer activity, positioning it as a candidate for further drug development^39,70.

4. Sansevieria trifasciata Prain:

Popularly known as the "snake plant," it has been used in traditional medicine to treat immune-related disorders and respiratory conditions. Its leaves contain alkaloids, terpenoids, and phenolics with antioxidant and antibacterial activities. Extracts show cytotoxicity against liver, breast, and colon cancer cell lines, while phytoremediation studies highlight its ability o absorb heavy metals from contaminated soil.^71-73

Significance of. Sansevieria suffruticosa:

Sansevieria suffruticosa possess antioxidant, antibacterial, and anticancer properties. Traditional uses include wound healing and treating ulcers, gout, and ear infections. High-performance liquid chromatography (HPLC) analysis identified compounds such as apigenin-7-glucoside and cinnamic acid, known for their anticancer potential. Apigenin-7-glucoside and cinnamic acid from this herb exhibits anticancer activity by inducing apoptosis, cell cycle arrest and genotoxic effects in Hela cells and melanoma cell

CONCLUSION:

The Sansevieria genus provides a valuable source of natural remedies and bioactive chemicals for cancer treatment with minimal side effects. Extensive research has unveiled numerous species within the genus, such as Sansevieria trifasciata, Sansevieria masoniana C, and Sansevieria liberica Gerome and Labroy, all of which exhibit strong anticancer properties. These species contain compounds with potent antineoplastic action, making them compelling subjects for further exploration.

CONFLICTS OF INTEREST:

The authors state that they have no conflict of interest.

AUTHOR CONTRIBUTIONS:

All authors equally contributed to the development of this review article.

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Received on 28.06.2024 Revised on 21.10.2024

Accepted on 19.12.2024 Published on 01.07.2025

Available online from July 05, 2025

Research J. Pharmacy and Technology. 2025;18(7):3404-3407.

DOI: 10.52711/0974-360X.2025.00491

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Creative Commons License.

1. Sansevieria liberica Gérome and Labroy:

2. Sansevieria roxburghiana Schult. and Schult. F34-39:

3. Sansevieria masoniana C:36, 63, 64,65