INTRODUCTION:

Premature labour occurs prior to the 37th week of pregnancy. ¹ There are commonly known risk factors for preterm labour like preterm birth in a previous pregnancy, a short cervix early in pregnancy in a pregnant woman, infection, and certain lifestyle and environmental factors. A review of the literature on preterm birth after COVID-19 infection found no statistically significant difference between early and late infection in pregnancy, nor between spontaneous and medically indicated preterm delivery. The current study efforts extend to understanding preterm deliveries during COVID-19 and risk factors that would help in prevention. ¹

One of the literature studies articulates the estimated risk of preterm birth after COVID-19 during pregnancy, also analysing different levels of disease severity and timing in their study. This study reveals that the time and severity of COVID-19 during pregnancy, further analysing the risk of preterm birth through observation of a large, dissimilar pregnancy group of pregnant women who were studied for severe COVID-19 in their late pregnancy, had a higher risk probability of preterm delivery. ²

The researcher of this study discovered there is a minimal risk due to milder disease earlier in pregnancy. The effect of severe COVID-19 and the entire, smaller increase with mild and moderate disease give the impression that they have occurred due to indicated preterm deliveries. The severe COVID-19-affected pregnancies with spontaneous preterm labour and rupture of membranes inducted spontaneous preterm delivery.²

This review study engine proceeded on objectives to bring out thoughtful, innovative, and insightful perceptions by analysing literature studies on preterm birth due to COVID-19 and the multiple ways that would provide protective measures to women.

METHODOLOGY:

This is a review study of premature delivery due to COVID-19 and the manifold protective measures for the risk involved for women concerning risk for preterm delivery and preventive measures taken during COVID-19 that are articulated in the literature. The secondary data is collected from the literature search in various electronic databases, such as PubMed, Google Scholar, and PubMed Central. The study chose 100 previous research, which was reduced to 70 after preliminary reading; 14 more were excluded since they had less significance for this study. Finally, 54 studies were thoroughly analyzed to determine the needs of the objectives.

Preterm birth in COVID and the Risks involved

Studies have revealed the proven fact that the appearance of coronavirus disease (COVID-19) was found to be unusually harmful to certain populations.^3,4. Especially in pregnant women one of the complications is preterm birth. One of the previous studies reveals that pregnant women with COVID-19 hospitalization are less likely to manifest symptoms of fever, cough, dyspnea, and myalgia; conversely, they have a high chance of getting admitted to the intensive care unit for invasive ventilation.⁵ But their pre-existing comorbidities—ethnicity, chronic hypertension, diabetes, advanced maternal age, and a higher body mass index—were found to increase the risk for severe COVID-19 outcomes in pregnancy.⁶ Studies have conceptualized that pregnant women with COVID-19 versus those without it are more likely to deliver preterm and have an increased risk of maternal death. ⁷ Thus, mothers are admitted to the intensive care unit, and their babies are admitted to the neonatal intensive care unit.⁸ Understanding COVID-19's effects on the pregnant population is not easily recognized. Previous literature studies have acclaimed a high risk of preterm birth among pregnant people with COVID-19. ⁹

As a result of COVID-19, the majority of mothers were discharged without major complications, and severe maternal morbidity resultantly perinatal deaths were reported.⁸ Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth.There are other associated well-known risk factors for severe maternal morbidity in pregnant women with no infection, including maternal age above 35 years, overweight, and obesity.⁹

Further evidence is required to establish if pregnancy itself can lead to severe forms of COVID-19 disease and whether risk factors for the general population are applicable to obstetric patients.⁸ Most women had a rapid onset of disease, developed severe hypoxia, and had significant findings on lung imaging. Fever on initial presentation was uncommon. All had an elevation of liver transaminases, CRP, and D-dimer. All women were discharged home in good health following multimodal and multidisciplinary approaches including intubation, prompt delivery, off-label use of experimental therapies (e.g., remdesivir, convalescent plasma), and Extra Corporeal Membrane Oxygenation (ECMO). Although there was a significant burden of prematurity, each neonate improved as expected with neonatal intensive care, and there was no evidence of vertical transmission.⁹

Various new literature studies have consistently reported an increase in preterm birth in women during pregnancy with COVID-19 ^18,
11; also, other literature studies have supported this fact that have observed a steady increase in preterm delivery in women at delivery during COVID. ^12,14.

According to one study, Seroprevalence and clinical spectrum of sars-cov-2 infection are similar between women in the first and third trimesters of pregnancy who have similar risk but women with symptoms who require hospitalization were higher in the third-trimester group than in the first-trimester group.

Data reported from case registries of pregnant women with COVID-19 has shown high risk in these women.¹¹ Based on a literature study, conceptualized COVID-19 diagnosis of high-risk pulmonary tuberculosis and early-term birth was more observed in populations with medical comorbidities.¹²

One of the literature study results showed preterm delivery, premature rupture of membranes, and admissions to the neonatal intensive care unit.¹⁵ Literature studies also draw the COVID-19 model has specified related issues with increased risk in caesarean section with preterm labour and preterm delivery.¹⁶ Advanced maternal-age pregnancy outcomes and risk factors for COVID-19 severity among pregnant women assessed maternal-age pregnancy outcomes also showed a higher risk of caesarean section and preterm delivery.¹⁵ Previous research has linked COVID-19 and preterm delivery to the biological effects of infection or immune response.

Severe COVID-19 late in pregnancy was measured with the risk of preterm delivery compared to patients with no COVID-19.¹⁵ This increase in risk is in line with an increase in medically indicated preterm deliveries, which include preterm caesarean sections. Other facts conceptualize a mild or moderate COVID-19 deliberate minimal risk. ¹⁵

It has been observed in the studies that the amniotic fluid and infant PCR test were positive during COVID-19 infection. One of the alarms in the literature on case studies about the possible vertical transmission of COVID-19 in pregnant women infected by SARSCoV2 is in critical cases that go through pregnancy termination. ¹⁸

One of the meta-analyses in the literature study signifies the relationship between COVID-19 and preterm delivery.¹⁹ Adverse pregnancy outcomes were associated with infection acquired at early gestational ages, more symptomatic presentation, myalgia symptoms at presentation, and use of oxygen support therapy. ²⁰

The literature reveals that pandemic influenza 2018 and maternal COVID-19 infection during pregnancy are associated with an increased risk of neonatal and perinatal complications. Observing estimates from previous studies, rates of premature birth in mothers infected with COVID-19 were significantly elevated from their pre–COVID-19 rates, and low birth weight in children of mothers infected with COVID-19 was also observed²¹. The scant literature evidence supported the notion that neonates are particularly vulnerable to direct harm from processes such as vertical transmission. ²²

UC San Francisco has led a large study on pregnant women with COVID-19 that states that they face a higher risk of having a preterm birth. For people with hypertension, diabetes, and/or obesity, as well as COVID-19, the risk of preterm birth is high. ²³

Risk prevention of preterm deliveries during COVID 19

During the COVID-19 pandemic, the effort to prevent the specific risks posed to pregnant patients and healthcare workers encouraged public and private hospitals, and private practitioners to proactively implement strategies to reduce the risk of exposure for both patients and medical staff. Maintaining a high-quality obstetric service in the setting of the exceptional COVID-19 pandemic situation.

Concerning preterm birth, the thought appeared in the past as an unavoidable consequence of human reproduction. In the current scenario, the concept of preterm birth has changed, and advances have been made in the preventable actions of preterm birth in some portions of cases.

One of the literature studies established support for soliciting evidence-based universal guidelines, which states that there is a need for original studies on the management of infected pregnant women to provide more information supporting soliciting guidelines for preventive measures. ²⁴

During COVID-19, pregnant women were guided to follow the CDC guidelines for preventing COVID-19 complications and take precautions to minimize their exposure, including staying at home as much as possible, regular hand washing, and social distancing. These precautions are similar to those for non-pregnant patients. ²⁵

During the time of COVID-19, information about COVID-19 and interim guidelines is developing rapidly. All through COVID-19 there are numerous studies and efforts to research epidemiology, virology, transmission, and symptoms and signs of COVID-19 in pregnant women and provided information based on studies that they are similar to non-pregnant patients. The early results indicated that there was no increased risk for these pregnant patients compared with non-pregnant patients ^{26, 27}.

Studies have analyzed the risk of obstetric complications such as an increase in preterm labour and preterm birth, and commonly encountered patients with moderate and severe infections that included pneumonia, perhaps, the risk near 1% prenatal vertical transmission is absent or low ^28,29.

Various multifaceted preventive health care programmes comprehensively work to help the public. An analysis of literature research reveals that preterm birth prevention programmes that operate on the government-funded universal health care system by health care practitioners and the general public lower the rate of early birth [30]. These programmes were the implementation of a state-wide. Observed literature from an Australian study revealed that the effectiveness of a state-wide prevention program in Western Australia showed a significant reduction in the rates of preterm birth in their tertiary-level centers and also overall in the state.³¹

Previous studies of the literature articulate that the most important cause of perinatal mortality and morbidity in the developed countries of the world is preterm birth (PTB). ³² There are a lot of efforts by the government organization along with health faculties of public hospitals were work for preterm birth prevention programs. One of the studies on strategies to prevent preterm birth has grown out of recent advances and knowledge in cases that are preventable by preterm birth.³³ The literature further articulates that effective implementation of these new clinical strategies is a challenge among all populations that undergo preterm delivery. ^{34, 35}

One study reveals that achievement through progestogen treatment to prevent preterm birth further expresses that resolving the mystery of preterm labour goes with the health of future generations; this is a difficult scientific challenge but one that is worthy of investment.³⁴

It has been conceptualized that late preterm birth and early term birth has a relationship with increasing adverse short- and long-term offspring outcomes. Observation of previous research on such preterm births and early term births attained by avoiding non-medically specified delivery prior to 39 weeks is beneficial in preventing the potential for stillbirth usually seen in prolonged gestation. ³⁶

In quality health programmes, preventing late preterm and early-term births is included within the goal of comprehensive preterm birth prevention strategies. Commonly, the majority of preterm births occur at late gestations; interventions can reduce the overall rate if they effectively prevent these births. Individual morbidity and mortality are greater for preterm infants’ health and also cause a socio-economic burden. Thus, various interventions aimed at reducing spontaneous preterm labour and preterm rupture of membranes across the gestational age spectrum. Literature studies indicate that avoidance of non-medically specified iatrogenic preterm birth is a strategy that prevents late preterm and early-term birth ³⁷.

Researchers such as Holland et al. suggest that 17% of late preterm births are potentially preventable and that 8% are purely elective; their provisions on evidence suggest a potential simple that would work as a set goal for rapid reduction ³⁸. The previous research that showed the efficacy of strategized approaches, such as a policy that was implemented eliminating decently elective deliveries before 39 weeks, was done to avoid deliveries, but the final decision was made by the attending physician, and information provided about the potential harms of early term birth without making any policy changes.

In this study, researchers stated that the program in 27 hospitals was broadly typical of the diversified US demographic; here, institutions were allowed to determine their own approach, which resulted in elective early-term delivery falling from 9.6% to 4.3% of all births that had taken place³⁹.

These USA-based programmed approaches hard-stop and soft-stop come out with a significant reduction in early-term deliveries.⁴¹ On the other hand, general education given in the early term deliveries is comparatively less effective. The hard-stop policy limited early-term deliveries, which eliminate decently elective deliveries before 39 weeks, have been found to be more effective than soft-stop deliveries, which are an approach to providing information about the potential harms of early-term birth. ⁴¹ During the Pandemic 2009 influenza in the population and whole geographic region across the state of Western Australia, the preterm birth prevention programmes that took their initiation to avoid non-medically indicated preterm birth prior to 38 weeks are one of several mechanisms to reduce the rate of preterm birth⁴². The articulated facts of the previous research study are that preterm birth is a determinant of neonatal mortality and morbidity that lead to long-term adverse consequences later in childhood and adulthood.^{43, 44} These findings from previous research indicate the need for additional research that focuses on changes in PTB and necessary changes in health-related behaviours during the pandemic. ⁴⁵

During the COVID-19 period, there was a rapid emergence of research information that indicated preterm birth is associated with higher risks commonly observed in cardiovascular, endocrine, metabolic, respiratory, renal, neurodevelopmental, and psychiatric patients who are in their early to mid-adulthood. These medically related morbidities lead to a moderate increase in mortality risks among men and women who were born preterm^46,47,48. Notwithstanding these increased risks, the majority of persons born preterm survive into adulthood without major comorbidities [49], and research has also found a good health-related quality of life in this population⁵⁰. The literature studies have articulated that preterm birth is recognized as a chronic condition that requires long-term follow-up, which enables preventive actions and timely detection and treatment of adverse effects throughout the life span.^{51, 46}. In the previous research, it is articulated that gestational age should be specified in birth histories that are routinely taken for medical record-keeping for patients of all ages.^{52,
53, 54.}

Discussion on conceptualized facts of the current review study

During the COVID-19 pandemic, there were a mounting number of studies that attempted to assess the indirect consequences of the pandemic on health aspects. One of these indirect consequences is the impact on birth outcomes, especially the prevalence of preterm birth.

Prolonged shedding of the virus is a unique feature of the disease observed in newborns during COVID-19. Therefore the risk is involved in extreme cases of premature infants seen with immature lungs and an immunocompromised status, suffering severe respiratory failure, and also undergoing a long clinical course.

A significant need for introducing suitable COVID-19 practices to prevent the spread of the disease. Indeed, the neonatal intensive care unit has a para-mounted need to prevent the spread of the disease. Infection infant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) needed implications of management in the neonatal intensive care unit.

The survival advantage conferred is enormously evident in the literature studies, and the data collected in intensive efforts to further protect facilities that provided new-borns care during the pandemic can also be used to invest more in rebuilding after the pandemic, given the gaps needed to reach universal health coverage.

Thus, based on all the available evidence, compared to the small risk of death due to COVID-19 for these vulnerable new-borns, the survival advantage conferred is observed enormously in the literature studies and the data collected in intensive efforts to further protect facilities that provided new-born care during the pandemic can also be used to invest more in rebuilding after the pandemic, given the gaps needed to reach universal health coverage.

One of the previous studies reveals data that calls for concerted efforts to protect facility-based new-borns care during the pandemic and to invest more in transformation after the pandemic to fill the given gaps and reach universal health coverage. Synthesising and sharing learnings regarding mitigation strategies is urgently needed to protect care for small and sick newborns and their mothers.⁵⁵

The guidelines are framed based on “Essential newborn care – a report of a technical working group”. ⁵⁸

Table 1:

Evidence-based facts signify rebuilding universal health care are:

Should receive skin-to-skin contact and breast milk feeding,

Mothers practicing frequent hand and respiratory hygiene,

Keeping mother and baby together and breastfeeding, with appropriate hygiene precautions.

Avoiding prolonged stays in the hospital

Wearing a mask when near the baby when needed

Regular disinfection of surfaces and objects e.g. stethoscopes and thermometers.

Maintaining a clean zone with no fever, no cough, and no contact in the postnatal and newborn units.

Though guidelines of observed shreds of evidence not supporting keeping mothers and babies together and breastfeeding during that neonatal infection following birth with a positive mother current study is convinced with keeping mothers and babies together and breastfeeding is essential to rebuild universal health care for new burns.

Concerning preterm birth, this study conceptualises that the survival benefit will prevail over the death risk involved due to COVID-19. It also conceptualises that following various precautionary measures and health-related guidelines derived from evidence-based studies should be mandatory. Some such guidelines are articulated in the above table.

One of the literature speaks about the survival benefit outweighs the small risk of death due to COVID-19. These researchers emphasize that preterm newborns are at risk, specifying Low and Low Middle-Income Countries (LMIC), where the consequences of disruptions are substantial. ⁵⁶ The literature on the study by Kasturba Medical College states that policymakers and healthcare professionals should protect services that ensure keeping mothers and newborns together, even if the mother is positive for SARS-CoV-2. ⁵⁶

Observing the literature study conducted in the UK states that neonatal infection in the first seven days following birth to a SARS-CoV-2-positive mother is not common, and in the rare case that it occurs, it is seen as mild. Despite national guidance, it is promoted to keep mothers and babies together and to breastfeed with proper hygiene precautionary practices.⁵⁷ This study also reveals that long hospital stays increase the risk of nosocomial infection for both the baby and the mother, which leads to a higher risk of preterm and newborn deaths.⁵⁷ The Technical Working Group signifies elements of essential newborn care even in-home deliveries, health centers, and hospitals. ⁵⁸

Not only during COVID should otherwise also adequate PPE, effective testing of staff and families, and strict adherence to infection control measures could mitigate these risks be mandatory. This study finds significance in the potential implications of early discharge criteria.

SUGGESTION:

The current study suggests that based on all the available evidence that articulates the risk of death due to COVID-19 is comparatively small compared to other aspects of health and healthcare facilities for these vulnerable new-borns, the survival advantage discussed and observed enormously in the literature studies and the data collected in intensive efforts to protect facilities to provided new-born care during the pandemic should rebuild even after for providing better health care. Intellectualizing the fact and extending the effort by using it to invest more in the transformation of the healthcare facilities initiated during the pandemic to fill the gaps needed to reach universal health coverage.

CONCLUSION:

This information can provide a better understanding of valued information concerning risk prevention for pre-term birth. The patients are provided with health and help generating education and counselling and preventive screening for needed patients. This review studies the risks for complications for pregnant women contracting with COVID specifically premature deliveries seen at an increased rate is analyzed. Drawn insights from the literature the review study has exemplified various measures for patient safety that would help the professionals have novel ideas to deal with these types of mishaps. With these insights and the current research priorities for future research are identified, which include the assessment of the long-term effects of preterm birth differently for all classes with regard to different races and economically diverse populations. The study also came out with further risk evaluations of preterm birth subtypes and the identification of protective factors that support the long-term health trajectories of preterm birth survivors. However, the current study concludes that the survival advantage conferred is enormously evident in the literature studies and that the data collected in intensive efforts to further protect facilities that provided newborn care during the pandemic should invest more in rebuilding after the pandemic, which would support universal health coverage.

CONFLICT OF INTEREST:

There is no conflict of interest between researchers.

REFERENCES:

1. Agrawal V, Hirsch E. Intrauterine infection and preterm labor. In Seminars in Fetal and Neonatal Medicine. 2012; 17(1): 12-19.

2. WB Saunders.Louisa H. Smith, Camille Y. Dollinger, Tyler J. VanderWeele, Diego F. Wyszynski, and Sonia Hernández-Díaz. 2022; 22: 775.

3. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: a systematic review and meta-analysis. Int J Infect Dis. 2020; 94:91–95.

4. Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, Debenham L, Llavall AC, Dixit A, Zhou D, Balaji R. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020 Sep 1; 370.

5. Della Gatta AN, Rizzo R, Pilu G, et al. Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obstet Gynecol. 2020; 223:36–41.

6. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99:823–829.

7. Sentilhes L, De Marcillac F, Jouffrieau C, et al. COVID-19 in pregnancy was associated with maternal morbidity and preterm birth. Am J Obstet Gynecol. 2020; 223:914.e1–914.e15.

8. Barbero P, Mugüerza L, Herraiz I, García Burguillo A, San Juan R, Forcén L, et al. SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19. J Matern Fetal Neonatal Med. 2022; 35:2648–54.

9. Romagano MP, Guerrero K, Spillane N, et al. Perinatal outcomes in critically ill pregnant women with coronavirus disease 2019. Am J Obstet Gynecol MFM. 2020; 2:100151. doi: 10.1016/j.ajogmf.2020.100151

10. Villar J, Ariff S, Gunier RB, et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 Infection: The INTERCOVID multinational cohort study. JAMA Pediatr. 2021; 175:817–826.

11. Crovetto F, Crispi F, Llurba E, et al. Seroprevalence and presentation of SARS-CoV-2 in pregnancy. Lancet. 2020; 6736:10–11.

12. Karasek D, Baer RJ, McLemore MR, Bell AJ, Blebu BE, Casey JA, et al. The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California. Lancet Regional Health Americas. 2021; 2.

13. Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, et al. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy and Childbirth. 2021; 21:273.

14. Ko JY, DeSisto CL, Simeone RM, et al. Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a coronavirus disease 2019 (COVID-19) Diagnosis. Clin Infect Dis. 2021; 73:S24–S31.

15. Vouga M, Favre G, Martinez-Perez O, et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep. 2021; 11:13898.

16. Romero R, Espinoza J, Gonçalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. In Seminars in reproductive medicine 2007 Jan (Vol. 25, No. 01, pp. 021-039). Copyright© 2007 by Thieme Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

17. Smith LH, Dollinger CY, VanderWeele TJ, Wyszynski DF, Hernández-Díaz S. Timing and severity of COVID-19 during pregnancy and risk of preterm birth in the International Registry of Coronavirus Exposure in Pregnancy. BMC Pregnancy and Childbirth. 2022 Oct 18; 22(1):775.

18. Zamaniyan M, Ebadi A, Aghajanpoor S, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery, maternal death, and vertical transmission in a pregnant woman with COVID‐19 infection. Prenatal Diagnosis. 2020 Dec; 40(13):1759.

19. Melo GC, Araújo KC. COVID-19 infection in pregnant women, preterm delivery, birth weight, and vertical transmission: a systematic review and meta-analysis. Cadernos de Saude Publica. 2020 Jul 17; 36

20. Dubey P, Reddy SY, Manuel S, Dwivedi AK. Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020 Sep 1; 252:490-501. 19.

21. COVID C. Response Pregnancy and Infant Linked Outcomes Team, Zambrano LD, Ellington S, Strid P et al (2020) Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status, United States. MMWR Morb Mortal Wkly Rep. 19; 69(44):1641-7

22. Maleki Dana P, Kolahdooz F, Sadoughi F, Moazzami B, Chaichian S, Asemi Z. COVID-19 and pregnancy: a review of current knowledge. Infez Med. 2020; 28(suppl 1):46-51.

1. Elizabeth Fernandez. COVID-19 During Pregnancy Associated with Preterm Birth People of Color Face Disproportionate Infection Risk While Pregnant. University of California San Francisco. August 9, 2021

23. Pountoukidou A, Potamiti-Komi M, Sarri V, Papapanou M, Routsi E, Tsiatsiani AM, Vlahos N, Siristatidis C. Management and prevention of COVID-19 in pregnancy and pandemic obstetric care: a review of current practices. InHealthcare 2021 Apr 15 (Vol. 9, No. 4, p. 467). MDPI.

24. COVID-19 During Pregnancy By Lara A. Friel , MD, PhD, University of Texas Health Medical School at Houston, McGovern Medical School Last review/revision Oct 2021 |Modified Sep 2022

25. Liu D, Li L, Wu X, et al: Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A preliminary analysis. Am J Roentgenol. Mar 18, 1–6: 2020

26. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014; 370:2211–2218.

27. Breslin N, Baptiste C, Gyamfi-Bannerman C, et al: COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM 2020

28. Schwartz DA: An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med Mar 17 2020.

29. Wang W, Xu Y, Gao R, et al: Detection of SARS-CoV-2 in different types of clinical specimens. JAMA Mar 11, 2020.

30. Newnham JP, White SW, Meharry S, Lee HS, Pedretti MK, Arrese CA, Keelan JA, Kemp MW, Dickinson JE, Doherty DA. Reducing preterm birth by a statewide multifaceted program: an implementation study. American Journal of Obstetrics and Gynecology. 2017 May 1; 216(5):434-42.

31. Pedretti MK, Arrese CA, Keelan JA, Kemp MW, Dickinson JE, Doherty DA. Reducing preterm birth by a state-wide multifaceted program: an implementation study.

32. Chang HH, Larson J, Blencowe H, et al. Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index. Lancet. 2013; 381:223-34.

33. Newnham JP, Dickinson JE, Hart RJ, Pennell CE, Arrese CA, Keelan JA. Strategies to prevent preterm birth. Front Immunol. 2014; 5:584.

34. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014; 345:760-5.

35. Lackritz EM, Wilson CB, Guttmacher AE, et al. A solution pathway for preterm birth: accelerating a priority research agenda. Lancet Glob Health 2013; 1:e328-30

36. White SW, Newnham JP. Is it possible to safely prevent late preterm and early term births? In Seminars in Fetal and Neonatal Medicine 2019 Feb 1 (Vol. 24, No. 1, pp. 33-36). WB Saunders.

37. Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth. Lancet. 2008; 371:75–84.

38. Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG Int J Obstet Gynaecol. 2006; 113:17–42.

39. Jamieson DJ, Theiler RN, Rasmussen SA. Emerging infections and pregnancy. Emerg Infect Dis. 2006; 12:1638–1643.

40. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014; 370:2211–2218.

41. Siston AM, Rasmussen SA, Honein MA, et al. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. JAMA. 2010; 303:1517–1525.

42. Liu L, Oza S, et al., Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. The Lancet. 2015 Jan 31; 385(9966):430-40.

43. Crump C. An overview of adult health outcomes after preterm birth. Early Human Development. 2020 Nov 1; 150:105187.

44. Yao X, Zhu L, Yin J, Wen J. Impacts of COVID-19 pandemic on preterm birth: a systematic review and meta-analysis. Public Health. 2022 Oct 19.

45. Crump C, Sundquist J, Winkleby MA, Sundquist K. Gestational age at birth and mortality from infancy into mid-adulthood: a national cohort study. The Lancet Child and Adolescent Health. 2019 Jun 1; 3(6):408-17.

46. Crump C, Sundquist K, Sundquist J, Winkleby MA. Gestational age at birth and mortality in young adulthood. JAMA. 2011 Sep 21; 306(11):1233-40.

47. Crump C. Preterm birth and mortality in adulthood: a systematic review. Journal of Perinatology. 2020 Jun; 40(6):833-43.

48. Crump C, Winkleby MA, Sundquist J, and Sundquist K. Prevalence of survival without major comorbidities among adults born prematurely. JAMA. 2019 Oct 22; 322(16):1580-8

49. 90. van der Pal S, Steinhof M, Grevinga M, Wolke D, Verrips G. Quality of life of adults born very preterm or very low birth weight: A systematic review. Acta Paediatrica. 2020 Oct; 109(10):1974-88.

50. Raju TN, Buist AS, Blaisdell CJ, Moxey‐Mims M, Saigal S. Adults born preterm: a review of general health and system‐specific outcomes. Acta Paediatrica. 2017 Sep; 106(9):1409-37.

51. Crump C. Medical history taking in adults should include questions about preterm birth. BMJ. 2014 Aug 1; 349.

52. Crump C. Birth history is forever: implications for family medicine. The Journal of the American Board of Family Medicine. 2015 Jan 1; 28(1):121-3.

53. Crump C, Sundquist K, Sundquist J. Adult outcomes of preterm birth. Preventive Medicine. 2016 Oct 1; 91:400-1.

54. Rao SP, Minckas N, Medvedev MM, Gathara D, Prashantha YN, Estifanos AS, Silitonga AC, Jadaun AS, Adejuyigbe EA, Brotherton H, Arya S. Small and sick new-born care during the COVID-19 pandemic: global survey and thematic analysis of healthcare providers’ voices and experiences. BMJ Global Health. 2021 Mar 1;6(3):004347.

55. Minckas N, Medvedev MM, Adejuyigbe EA, Brotherton H, Chellani H, Estifanos AS, Ezeaka C, Gobezayehu AG, Irimu G, Kawaza K, Kumar V. Preterm care during the COVID-19 pandemic: a comparative risk analysis of neonatal deaths averted by kangaroo mother care versus mortality due to SARS-CoV-2 infection. EClinical Medicine. 2021 Mar 1; 33:100733.

56. Gale C, Quigley MA, Placzek A, Knight M, Ladhani S, Draper ES, Sharkey D, Doherty C, Mactier H, Kurinczuk JJ. Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. The Lancet Child and Adolescent Health. 2021 Feb 1; 5(2):113-21.

57. World Health Organization. Essential newborn care report of a technical working group. 2000

Received on 02.05.2023 Modified on 29.05.2023

Research J. Pharm. and Tech 2023; 16(6):3009-3015.

DOI: 10.52711/0974-360X.2023.00497