Formulation and Evaluation of Oral Dispersion Tablet of Telmisartan

 

Mahesh PG1*, Raman S.G. 2

1Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai 600117.

2Department of Chemistry, School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University,

Puducherry, India

*Corresponding Author E-mail: pgmahesh83@gmail.com

 

ABSTRACT:

Aim: Telmisartan is used for treatment of a number of infections including infection of joints and bones, gastroenteritis, malignant obits external, respiratory tract infections, cellulites, urinary tract infections, anthrax, skin structural infections, typhoid fever and it also used in treatment of community acquired pneumonia, chronic bacterial prostitis, nosocomial pneumonia etc. Objective: Difficulty in swallowing (dysphasia) is a common problem of all age groups, especially the elderly and pediatrics, because of physiological changes associated with these groups. Conclusion: In the present work it has been observed from all formulations of Pre compression and post compression studies were given within the limit of values. The in vitro dissolution data, F1 (combination of different super disintegrates) formulation was found that the drug release is best and the cumulative % of drug release was 90.88 % respectively, when compared to other formulation.

 

KEYWORDS: Gastroenteritis, malignant obits external, dysphasia.

 

 

INTRODUCTION:

Oral dispersible tablets are solid single unit dosage forms. They are well accepted by wide range of population especially as pediatric and geriatric patients who have difficulty in swallowing of conventional dosage forms01. Those are placed on tongue, allowed to disperse or dissolve in saliva without the need of water, frequently releasing of the drug for quick onset of action. Some drugs are absorbed from mouth, pharynx and esophagus as saliva passes down to stomach.

 

EXPERIMENTAL METHODS:

PRE-FORMULATION STUDIES:

Pharmaceutical methods substances.

 

STANDARD CURVE OFTELMISARTAN:

Sodium hydroxide solution, 0.2M:

8gm of sodium hydroxide was dissolved in 1000ml distilled water and it gives 0.2M solution55.

 

STANDARD CURVE OF TELMISARTAN:

Table No.1: Standard curve of Telmisartan in Phosphate buffer (pH 6.8)

S. No

Concentration (μg /ml)

Absorbance (290nm)

1

0

0.00

2

2

0.234

3

4

0.462

4

6

0.686

5

8

0.929

6

10

1.124

 

Figure No.1: Standard curve of Telmisartan in Phosphate buffer (pH 6.8)

 

METHOD OF PREPARATION:

Preparation of Telmisartan tablets:

Direct compression technique:

Each tablet weight=200mg

 

PRECOMPRESSION STUDIES OF POWDER BLENDS:

Angle of repose

θ = Tan-1 (h/r)

Where,

θ = Angle of repose,

h = Height of the powder cone,

r = Radius of the powder cone.

 

Table No.2: Different Formulation of Telmisartan Oral Dispersible Tablets

S. No

Formulation Code

Drug

SSG

CCS

Mannitol

Sodium Saccharin

Magnesium Stearate

Mint flavor

1

F1

10

5

-

78

5

2

q. s

2

F2

10

10

-

73

5

2

q. s

3

F3

10

-

5

78

5

2

q. s

4

F4

10

-

10

73

5

2

q. s

5

F5

10

5

5

73

5

2

q. s

 

RESULTS AND DISCUSSION:

PRE-FORMULATION STUDIES:

The present study was undertaken to formulate Telmisartan oral dispersible tablets with three polymers namely., CCS and SSG and in combination of three Super disintegrants and by dry granulation technique.

 

Table no:3 Pre compression studies of powder blend

S. No

Formulations

Hardness Test (kg/cm)

Thickness Test (cm)

Friability Test (%)

% of Weight variation test

Estimation of Drug Content

1

F1

2.34

0.35

0.185

99.4

98.25

2

F2

2.35

0.35

0.206

99.5

96.39

3

F3

3.24

0.35

0.234

99.5

96.64

4

F4

2.54

0.35

0.264

99.6

97.57

5

F5

2.25

0.35

0.234

99.7

95.75

 

Table no: 4 post compression studies of Telmisartan oral dispersion tablet

S. No

Formulations

Bulk Density

(gm/cm3)

Tapped Density

(gm/cm3)

Angle of Repose

(θ)

Carr's Index (%)

Hausner's Ratio

1

F1

0.382

0.375

31.34

10.16

1.329

2

F2

0.355

0.365

35.21

6.34

1.176

3

F3

0.352

0.369

32.91

9.25

1.203

4

F4

0.386

0.319

32.40

6.19

1.165

5

F5

0.339

0.361

34.09

9.25

1.003

 

Table No.5: Disintergration studies of Telmisartan oral dispersible Tablets

S. No

Formulations

Disintegration time (sec)

Wetting time (sec)

1

F1

19

18

2

F2

20

16

3

F3

25

18

4

F4

23

17

5

F5

25

16

 

Figure No.2: FTIR spectrum of Telmisartan

 

Figure No.3: FTIR spectrum of SSG

 

INVITRO DRUG RELEASE STUDY:

Tablets of all the formulations were subjected for invitro release studies. The results are presented in Table no. (5).

 

Fig no:4 formulation-1(F1)

 

DISCUSSION:

Oral dispersible tablets of Telmisartan were prepared by direct compression method. The prepared Oral dispersible tablets are round in shape. Microscopic examination of tablets from each formulation batch showed circular result.

 

CONCLUSION:

In the present work it has been observed from all formulations of Pre compression and post compression studies were given within the limit of values. The in vitro dissolution data, F1 (combination of different super disintegrants) when compared to other formulation.

 

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Received on 21.09.2019           Modified on 27.10.2019

Accepted on 23.11.2019         © RJPT All right reserved

Research J. Pharm. and Tech. 2020; 13(7): 3184-3186.

DOI: 10.5958/0974-360X.2020.00563.6