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0974-360X (Online)
REVIEW ARTICLE
Medicinal Uses of Dioscorea bulbifera- A Review
Fathima Mariyam Niyas
1st Year BDS, Saveetha Dental College and
Hospital, Chennai, India
*Corresponding Author E-mail: marlog7494@gmail.com
ABSTRACT:
Dioscorea
bulbifera is
a tribal plant, which belongs to the family Dioscoreaceae assigned to the order
dioscorales. It is native to tropical Asia and sub-Saharan Africa.
Dioscorea
bulbifera
posses potentional therapeutic uses. It
is found throughout India particularly in warmer places and is known as Yam or
Air potato. Many tests prove phytochemically it contains flavnonoids, saponins,
steroids, cardiac glycosides, terpenoids.
This review will enumerate the free radical scavenging and anti-oxidant
activity in nature. Other aspects covered include anti-microbial, analgesic,
anti-inflammatory and gastroprotective functions. A large number among them occur in the wild
state. Dioscorea species are
distributed in nearly throughout India.
KEY WORDS: Dioscorea bulbifera, Analgesic, antioxidant, flavonoids,
saponins, terpenoids, cardiac glycosides.
INTRODUCTION:
Dioscorea
bulbifera is
a tribal plant, which belongs to the family Dioscoreaceae assigned to the order
dioscorales. It is a climber plant with tuberous root. Dioscorea is a large genus of annual twinning herbs, distributed
throughout the moist tropics of the world, which extends into warm temperate
regions. It is commonly known as air potato, air yam or bulbil-bearing yam [1].
In India it is known as Gonth, Kolkand, Varaheekand. It is a climber plant with
tuberous root [2]. The tuber is edible when either boiled or cooked [3,4]. One
teaspoon of tuber powder and water taken in orally is a single dose cures for
abdominal [5]. Traditionally Dioscorea
bulbifera have been used to lower glycemic index, therefore it provides
better protection against diabetes and obesity [6]. In traditional Indian and
Chinese medicine it is widely used in the treatment of sore throat, goiter,
gastric cancer and carcinoma of rectum [7,8].
Received on 30.04.2015
Modified on 11.05.2015
Accepted on 28.07.2015 ©
RJPT All right reserved
Research J. Pharm. and Tech. 8(8): August,
2015; Page 1059-1062
DOI: 10.5958/0974-360X.2015.00182.1
In places like
Cameroon and Madagascar the bulbs are pounded and applied to abscesses, boils
and wound infections [9]. In India the bulbs are used to treat piles,
dysentery, and are applied to ulcers, pain, and inflammation [10]. This tuber contains the plant reserves,
mainly starch, and it is often incorporated in the human diet. The tuber not
only stores food but also many of the plants as secondary metabolites, which
are commonly referred to as anti-nutritional factors [11].
Classification:
Kingdom: |
Plantae |
(unranked): |
Angiosperms |
(unranked): |
Monocots |
Order: |
Dioscoreales |
Family: |
Dioscoreaceae |
Genus: |
Dioscorea |
Species: |
D. bulbifera |
Distribution:
It is native to
tropical Asia and sub-Saharan Africa, air potato was introduced by ancient
Polynesians throughout much of the South Pacific where it is now considered
invasive. It was brought to the Americas from Africa during the slave trade
[22] and brought to Florida in 1905 [23]. It is found throughout the state from
Escambia Country in Panhandle to the Florida Keys.
Air potato is a
member of the yam family. Yams are cultivated for their edible underground
tubers in western Africa, where they are important commodities. However,
uncultivated species- such as air potato- are generally bitter and even
poisonous [24]. About 50 species of Dioscorea
are found in India. A large number among them occur in the wild state. Dioscorea species are distributed in
nearly throughout India except in the dry north-western regions. They are found
growing at elevations of 8000-15000 ft. in Himalayas. In its wild state, it is
extremely bitter. Under cultivation the plant loses its bitterness and is much
grown for the tubers, which are roasted and eaten. The tuber is used by the
tribal population of central India as a food particularly in Madhya Pradesh,
Chattisgurh, Jharkhand and Orissa [2].
Descriptive:
Air potatoes are
vigorously twinning herbaceous vine, often arising from an underground tuber.
Freely branching stems grow to 60 ft. in length. Stems are round or slightly
angled in cross-section and twined to the left [25]. Air potato can grow
extremely quickly, roughly 8 inches per day. It typically climbs to the tops of
trees and has a tendency to take over native plants. New plants develop from
bulbils that form on the plant, and these bulbils serve as a means of
dispersal. The aerial stems of air potato die back in winter, but resprouting
occurs from bulbils and underground tubers. The primary means of spread and
reproduction are via bulbils. The smallest bulbils make control of air potato
difficult due to their ability to sprout at a very small stage [26].
Phytochemical
constituents:
When subjected
to phytochemical screening, the presence of flavonoids,saponins, cardiac
glycosides and terpenoids in methanol extracts. High flavonoids and terpenoids
was also found in other species of D.bulbifera.
Cholesterol and alkaloid have not been detected in most studies [11]. Yams
have been well respected by the herbalist community for generations due to the
presence of steroidal drug, i.e., diosgenin. It is used as a precursor for the
synthesis of hormones and corticosteroids which improve fertility in males
[12,13]. Saponins have a natural tendency to ward off microbes which makes them
a good candidate for treatment of fungal and yeast infections. These compounds
serve as natural antibiotics, which help the body to fight infections and
microbial invasion [14]. Cardiac glycosides have been used as stimulant in case
of cardiac failure[15,16]. Phenolic content were found to be significantly high
in methanolic extracts [17].
Free
radical scavenging and anti-oxidant properties:
Free radicals
are the spontaneous byproducts in biochemical systems during metabolic
processes that can cause extensive damage to tissues and biomolecules leading
to various severe clinical implications particularly diabetes mellitus, chronic
inflammation, neurodegenerative disorders and cancer [18,19]. Consumption of
natural antioxidants from food supplements and traditional medicines constitute
an alternative solution to the problem. Phenolic and flavonoid compounds are
reported to possess both potent antidiabetic and free radical scavenging
activity [20].
Present studies
reveal that hydro alcohol extracts of Dioscorea
bulbifera tubers contains carbohydrates, glycoside, alkaloids and proteins
and its physicochemical analysis (ash values and extractive values) shows the
presence of foreign particles as mentioned in pharmacopoeia [21].
Analgesic
and anti-inflammatory properties:
Aqueous and methanol
extracts from the bulbils of Dioscorea
bulbifera var Sativa have a potent antinociceptive effect against chemical
pains provoked by acetic acid or formalin and a slight activity against
mechanic pain induced by pressure. These extracts also present important anti-
inflammatory effects on acute edema induced by formalin. The acetic
acid-induced abdominal constriction method is widely used for the evaluation of
peripheral antinociceptive activity [27] because it is very sensitive and able
to detect antinociceptive effects of compounds at dose levels that may appear
inactive in other methods [28,29]. Local peritoneal receptors are postulated to
be partly involved in the abdominal constriction response [30]. In the formalin tests, there is a
distinctive biphasic nociceptive response termed early and late phases. Drugs
that act primarily on the central nervous system inhibit both phases equally
while peripherally acting drugs inhibit the late phase [31, 32]. The early
phase is probably a direct result of stimulation of nociceptors and reflects
centrally mediated pain while the late phase is due to inflammation with a
release of serotonin, histamine, bradykinin and prostaglandins [33] and at
least to some extent, the sensitization of central nociceptive neurons
[33,34,35]. Suppression of both phases of pain was observed in animals with
aqueous and methanol extracts. These results lend strong credence to the
presence of both central and peripheral affects. Since D. bulbifera extracts are very efficient on visceral pain induced
by acetic acid and on late phase of pain induced by formalin all mediated by
histamine, serotonin, bradykinin and prostaglandins, it is possible that these
extracts possess anti-inflammatory activities[36].
Gastroprotective
properties:
Dioscorea
bulbifera
extracts have been proven to show gastroprotective function, by protecting
gastric damages caused by indomethacin casued in wistar albino rats [21]. This
indicates that D. bulbifera showed
potent gastroprotective effect against NSAIDs induced gastric damage at all
doses.
Anti-Bacterial
activity:
The research in
anti-microbial assay of six compounds isolated Dioscorea bulbifera is resistant against Mycobacterium and gram
negative bacteria and among six three was considered as potential antimicrobial
drugs to fight against MDR bacteria.[37]
CONCLUSION:
Research has
shown that the air potato contains flavonoids, saponins, cardiac glycosides and
terpenoids in methanol extracts. It is shown to lower the glycemic index hence
possess potent anti-diabetic properties. They show free radical scavenging and
anti-oxidant activity therefore the air potato serves as a source of natural
anti-oxidant as an alternative. It shows potent antinociceptive effect against
pains induced by aceticacid, formalin and pressure. Since oxidative stress is a
key player in several diseases such as cancer, diabetes mellitus,
artherosclerosis, cardiovascular diseases, ageing and inflammatory diseases,
results from an imbalance between formation and neutralization of prooxidants.
It shows high gastroprotective as well antimicrobial properties. The
Dioscoreacea family is of high medicinal importance in both edible and extract
forms.
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