2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  9

Year :  2019

Pages :   4225-4230

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases



Address:   Faruk Alam
Associate Professor, Faculty of Pharmaceutical Sciences, Assam down town University, Gandhi Nagar, Panikhaiti, Guwahati, Assam -781026
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00726.1

ABSTRACT:
New substituted pyrazoles were prepared from Benzylidene acetophenone (chalcone) and hydrazine hydrate as starting materials through 2-chloro-1-(3, 5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-ethanone as intermediates. These intermediates on reaction with different amine (aliphatic and aromatic) in alcohol, finally converted into corresponding pyrazoles and were produced in excellent yields. The synthesized compounds were characterized by their physical properties (M.P and TLC) and UV, IR, 1HNMR, Mass spectroscopic studies respectively. The antimicrobial activity of synthesized pyrazoles was assessed by agar cup method. All the synthesized compounds were screened for the antimicrobial, Anthelmintic and haemostatic activity against some gram (+ve), Gran (-ve) organisms, Eudrilus eugenia and Human venous blood. The compounds exhibited moderate to good activity when compared with standard one.
KEYWORDS:
Synthesis, antimicrobial activity, Anthelmintic activity, haemostatic activity.`
Cite:
Faruk Alam. Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases. Research J. Pharm. and Tech 2019; 12(9):4225-4230.
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