2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  9

Year :  2019

Pages :   4073-4079

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Controlled Release of Cefixime using Sodium Carboxymethyl Cellulose Polymer



Address:   Kawther Abd Alwahid Abdulhameed*, Nadeerah Abdulhameed Salih
Department of Chemistry, College of Abn ALhaythem for Science, University of Baghdad, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00701.7

ABSTRACT:
Environmentally benign and efficient route of synthesis of PAA-g-SCMC was prepared via irradiation (800W) using modified household microwave alone (without using initiator). PAA-g-SCMC polymer before and after loading with the drug was confirmed on FT-IR spectrophotometer and SEM. SCMC polymer was also used to extend the release of antibiotic namely, Cefixime. Buffer solutions of pH 7.2 and 1.2 were used as the medium for the release of drug to simulate the pH media of small intestine and stomach respectively. We used UV-visible spectrophotometer fo imbibing measuring solution of antibiotic for Cefixime respectively at 285nm. The antibiotic release was done at different temperature (25°C, 37°C). Generally, there lease was increased at pH 7.2 and temperature at 37°C. The results obtained from the grafted polymers were better than the non grafted polymers concerning the controlled release of the drug.
KEYWORDS:
Cefixime, SCMC polymer, Buffer solutions, deionized water (D.W), grafted polymer PAA-g-SCMC.
Cite:
Kawther Abd Alwahid Abdulhameed, Nadeerah Abdulhameed Salih. Controlled Release of Cefixime using Sodium Carboxymethyl Cellulose Polymer. Research J. Pharm. and Tech. 2019; 12(9): 4073-4079.
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