2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  8

Year :  2019

Pages :   3764-3772

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Ramipril Fast Dissolving Tablet using Solid Dispersion



Address:   Hitendra Choudhary, Bhagwan Yadav*, Pankaj Patel, Prabhat Das, Dr. Sujit Pillai
Dept. of Pharmaceutics, GRY Institute of Pharmacy Borawan Khargone (M.P)
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00645.0

ABSTRACT:
Solubility is a key parameter for oral bioavailability of poorly water soluble drugs. Ramipril is sparingly soluble in water which affects the absorption of drug via GIT, and ultimately makes the drug with low bioavailability. In the present study is solubility enhancement of Ramipril by solid dispersion technique. Solid dispersion of Ramipril is prepared by using two polymers ie: Polyvinyl Pyrrolidone (PVP K30) and Polyethylene Glycol 4000 (PEG 4000) in different ratios (1:1, 1:2, 1:3) using solvent evaporation method. On the basis of % drug content and solubility study S.D.2 and S.D.5 solid dispersion were selected an taken for formulation of fast dissolving tablet of Ramipril. On evaluating various FDTs of Ramipril the best formulation was found to be F6 (1:2 PEG 4000) showed disintegration time was 28 sec. and cumulative percentage drug release 97.68 % in 40 min.
KEYWORDS:
Bioavailability, Ramipril, PVP K30, PEG 4000, Solid dispersion.
Cite:
Hitendra Choudhary, Bhagwan Yadav, Pankaj Patel, Prabhat Das, Sujit Pillai. Formulation and Evaluation of Ramipril Fast Dissolving Tablet using Solid Dispersion. Research J. Pharm. and Tech 2019; 12(8): 3764-3772.
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