2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  8

Year :  2019

Pages :   3703-3708

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice



Address:   Saikhu A. Husen1,2, Arif N. M. Ansori3, Suhailah Hayaza1, Raden J. K. Susilo1, Ayu A. Zuraidah4, Dwi Winarni1,2, Hunsa Punnapayak1,5, Win Darmanto1*
1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia.
2Animal Histology Laboratory, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia.
3Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia. 4Faculty of Psychology, Universitas Airlangga, Surabaya, 60115, Indonesia.
5Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00633.4

ABSTRACT:
The aims of this study were to determine the effect of various fractions of okra pods extract (VOPE) to the changes of fasting blood glucose, serum insulin, and GLUT4 density on streptozotocin-induced type-2 diabetic mice. This study employed 36 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semi-polar), and EP (polar). VOPE and acarbose were administered orally for 14 days in streptozotocin-induced type-2 diabetic mice. Mice with type-2 diabetes mellitus were induced by the intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On 15th day, mice were terminated. The data of fasting blood glucose, serum insulin, and GLUT4 density were analyzed and interestingly it showed that the administration of VOPE could ameliorate the fasting blood glucose, serum insulin, and GLUT4 density. Therefore, it can be suggested that VOPE can be regarded as a promising antidiabetic agent in the streptozotocin-induced diabetic mice.
KEYWORDS:
Abelmoschus esculentus Moench, Fasting Blood Glucose, Serum Insulin, GLUT4 Density, Diabetic Mice.
Cite:
Ayu A. Zuraidah, Dwi Winarni, Hunsa Punnapayak, Win Darmanto. Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice. Research J. Pharm. and Tech 2019; 12(8):3703-3708.
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