2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  8

Year :  2019

Pages :   3649-3653

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In vitro Evaluation of Gastro Retentive Drug Delivery System of Lansoprazole



Address:   Veeranagoud Biradar1, Jeevan Matada Basavarajaiah2*, Myat Thu Thu Win3, Leneena Gudugunta4, Suresh KV5 , Sathiyavathi Mahendra Kumar 6, Neeraja Turagam7, Lavanya Priya8
1SM Pharmaceuticals SDN. BHD, Sungai Petani, Malaysia.
2Department of Oral Pathology, AIMST University, Malaysia.
3Department of Pharmacology, Faculty of Medicine AIMST University, Malaysia
4Department of Conservative and Endodontic, AIMST University, Malaysia.
5Department of Oral Medicine and Radiology, Faculty of Dentistry, SEGI University, Malaysia
6Department of Pedodontics, AIMST University, Malaysia.
7Department of Prosthodontics, AIMST University, Malaysia.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00622.X

ABSTRACT:
Objective: Drug given by orally is the simplest and easiest way in compared to other routes. But, the oral bioavailability of drugs is lower than other routes because it is influenced by first pass hepatic effect and absorption factors.To overcome therestrictions of conventional dosage forms like poor compliance, variability of drug leveland increase the bioavailability of the drugs for avoiding frequent dosing and subsequent degradation of drug in intestine, floating drug delivery system of lansoprazolewas explored in this study. Materials and Methods: By using floating tablets formulation, HPMC K4M and HPMC K15M were used as matrix forming agent. Microcrystalline cellulose, talc, sodium bicarbonate, citric acid and magnesium stearate (lubricating agent) are included in this formulations. The lack of any drug, polymers and excipients interactions were confirmedby Fourier transform infrared spectroscopy. Results: The results showed that F4 of HPMC K4M and F6 of HPMC K15M gave maximum release of drug upto 100% within 24hrs. All formulations were examined for five different models viz. zero and first order, Higuchi matrix, Peppas model and Hixson-Crowell equations and all the formulations according toPeppas model. Conclusion: This study showed that F4 of HPMC K4M series and F6 of HPMC K15M canbe stable for 30 days at 40ºC and 75%relative humidity (RH) stability. It is suggested that a controlled release lansoprazole floating tablets may be developed from our study which will be beneficial in clinical practice.`
KEYWORDS:
Lansoprazole, Floating drug, Bioavailability.
Cite:
Veeranagoud Biradar, Jeevan Matada Basavarajaiah, Myat Thu Thu Win, Leneena Gudugunta, Suresh KV , Sathiyavathi Mahendra Kumar, Neeraja Turagam, Lavanya Priya. In vitro Evaluation of Gastro Retentive Drug Delivery System of Lansoprazole. Research J. Pharm. and Tech 2019; 12(8):3649-3653.
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