2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  8

Year :  2019

Pages :   3643-3648

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Phytochemical Analysis and In vitro Antioxidant activity of extracts of Justicia wynaadensis leaves



Address:   Sahana Chavan C. S1, Ramakrishna Rao3, Saraswathi Raman D. N2, Somashekaraiah B. V1*
1Department of Chemistry, PG and Research Centre, St. Joseph’s College, Bengaluru-27.
2Department of Botany, PG and Research Centre, St. Joseph’s College, Bengaluru-27.
3Department of Chemistry, GITAM University, Bengaluru Campus-562163
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00621.8

ABSTRACT:
Free radicals are constantly formed in the cell causing oxidative stress when the precarious balance is broken, in favour of free radicals proceeding to variety of pathophysiological disorders. Antioxidants that can scavenge free radicals are thus effective in ameliorating the progress of oxidative damage. The present study was designed to estimate phenolics and flavonoids present and to evaluate the antiradical activity of Justicia wynaadensis leaf extracts. Series of in vitro models like DPPH, lipid peroxidation, reducing ability, superoxide scavenging, nitric oxide scavenging, hydroxyl scavenging and hydrogen peroxide scavenging activity were employed to assess the antioxidant activity of different extracts of J. wynaadensis. Few fractions of J. wynaadensis leaf extracts showed antioxidant activity comparable to that of the standards such as BHT, Ascorbic acid, Quercetin, Curcumin and Mannitol to certain extent. The in vitro assays revealed the effective antioxidant and free radical scavenging capacity of the leaf extract of J. wynaadensis.
KEYWORDS:
Justicia wynaadensis, antioxidant, 1,1-Diphenyl-2-picryl hydrazyl, free radical scavenging activity.
Cite:
Sahana Chavan C. S, Ramakrishna Rao, Saraswathi Raman D. N, Somashekaraiah B. V. Phytochemical Analysis and In vitro Antioxidant activity of extracts of Justicia wynaadensis leaves. Research J. Pharm. and Tech 2019; 12(8):3643-3648.
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