2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   3053-3058

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis, Characterization and Antibacterial activity of Disulfide and Sulfone Compounds Derivatives from Benzimidazole



Address:   Muayedahmed Redayan1*, Ali Hussein ali1, Zainabalaa Monem1
1Department of Chemistry, College of Education for Pure Sciences, Diyala University, Diyala, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00517.1

ABSTRACT:
This study aimed to prepare a series of disulfide and sulfone compounds derivatives from benzimidazole. The target compounds were prepared by three steps: First step comprise synthesis of 2-mercaptobenzimidazole derivatives from reaction of 4- (un)substituted-o-pheneylenediamine with carbon disulfide, In the second step: Alkylation of the 2-mercaptobenzimidazole derivatives with different alkyl halides to obtain thioether compounds. Final step: include oxidation of 2-mercaptobenzimidazole derivatives to yielded disulfide compounds while oxidation of thioether compounds gave sulfone derivatives by using hydrogen peroxide as oxidizing agent. The chemical structures of all synthesized compounds were confirmed by FT-IR and some by 1H and 13C-NMR.Some selected compounds were tested in vitro for their antibacterial activity by disc diffusion method against two types of Gram-positive bacteria namely (Staphylococcous aureus, Bacillus subtilis) and Gram-negative bacteria namely (Pseudomonas aeruginosa, Escherichia coli). The results displayed that most of the prepared compounds have a good antibacterial activity when compared with the standard antibiotic ampicillin and ciprofloxacin.
KEYWORDS:
2-mercaptobenzimidazole, sulfone compounds, thioether, alkylation.
Cite:
Muayedahmed Redayan, Ali Hussein ali, Zainabalaa Monem. Synthesis, Characterization and Antibacterial activity of Disulfide and Sulfone Compounds Derivatives from Benzimidazole. Research J. Pharm. and Tech. 2019; 12(6): 3053-3058.
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