2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   3024-3028

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Immediate release tablets of Topiramate using Sodium starch glycolate



Address:   Kanhu Charan Panda, Niranjan Panda, Chinmaya Keshari Sahoo, Jimidi Bhaskar, D. Venkata Ramana 1Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001
2Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014
3Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115.
4Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00511.0

ABSTRACT:
The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.
KEYWORDS:
IRT, topiramate, SSG, drug release, FTIR spectroscopy.
Cite:
Kanhu Charan Panda, Niranjan Panda, Chinmaya Keshari Sahoo, Jimidi Bhaskar, D. Venkata Ramana. Formulation and Evaluation of Immediate release tablets of Topiramate using Sodium starch glycolate. Research J. Pharm. and Tech. 2019; 12(6): 3024-3028.
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