2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   2936-2942

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic



Address:   Joni Tandi1*, Rama Danthy1, Purwaningsih1, Hadi Kuncoro2
1Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia
2Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00494.3

ABSTRACT:
To observed secondary metabolite compounds in the purpleeggplant skin fruit ethanol extract, the effect and effective dose on blood glucose levels and regeneration of pancreatic ß cells of white rats male Hypercholesterolemia-Diabetic. This research is a laboratory experiment with a Phytochemical assay using a specified reagent for the ethanol extract of purple eggplant skin. The effect and effective dose on blood glucose levels and regeneration of pancreatic ß cells animal model using posttest randomized controlled-group design. A total of 30 rats were divided into six groups. Group I; normal control given standard feed: group II; negative control is given Na CMC 0.5%, high cholesterol feed and induced by streptozotocin 30 mg/kg BW; experimental groups were given extract of ethanol from purple eggplant skin each with dose 25, 50 and 100 mg/kg BW, high cholesterol feed, and streptozotocin 30 mg/kg BW. The data obtained were analyzed using one-way ANOVA test at 95% confidence level and continued with LSD Post Hoc test and description of histologic damage level of the pancreaswas analyzed by Kruskal-Wallis test followed by Mann-Whitney test for observed the difference between treatments. Extracts ethanol of purple eggplant skinaffect blood glucose levels and pancreatic ß cell regeneration and an effective dose is a dose of 25 mg/kg body weight was the most effective extract.This research confirm that the ethanol extract from purple eggplant skin (Solanum melongena L) affect blood glucose levels and pancreatic ß cell regeneration.
KEYWORDS:
Solanum melongena L, Purple Eggplant, Diabetic, Histology, Pancreatic.
Cite:
Joni Tandi, Rama Danthy, Purwaningsih, Hadi Kuncoro. Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic. Research J. Pharm. and Tech. 2019; 12(6):2936-2942.
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