2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   2929-2935

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Solubility Enhancement of Lumefantrine by Hot Melt Extrusion Process



Address:   Rakshith Shetty1, Vaishnavi Tallapaneni2, Sreenivasa Reddy M2, Nayanabhirama Udupa2, Srinivas Mutalik2, Vijay Kulkarni*1, Vinay Rao1, Aravind Kumar Gurram1
1STEER Life India Pvt Ltd, Bengaluru 560058, Karnataka State, India.
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2019.00493.1

ABSTRACT:
Lumefantrine is a BCS class -II drug having a poor aqueous solubility. There is a need for improvement in solubility, in order to enhance the therapeutic efficacy and reduce the dose. Hence in the present work, the solubility of lumefantrine is enhanced by formulating solid dispersions of lumefantrine using a hot melt extrusion process in a twin-screw processor using three different polymers such as Kollidon VA64, Soluplus and HPMC AS at a weight ratio of 1:2, 1:3 and 1:4, processed at different barrel temperatures and screw speeds. The obtained solid dispersions were characterized by differential scanning calorimetry and solubility studies. Solid dispersions prepared with KollidonVA64 and Soluplus showed a clear extrudate indicating a complete amorphous conversion of the lumefantrine at all the three ratios evaluated. Increase in polymer concentration, increased the solubility of the lumefantrine. With Kollidon VA 64 and Soluplus, lumefantrine to polymer ratio of 1:4 showed the highest increase in solubility, compared to that of the pure lumefantrine.
KEYWORDS:
Lumefantrine, Polymers, Twin screw extrusion, Solid dispersion, Solubility.
Cite:
Kulkarni, Vinay Rao, Aravind Kumar Gurram. Solubility Enhancement of Lumefantrine by Hot Melt Extrusion Process. Research J. Pharm. and Tech. 2019; 12(6):2929-2935.
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